Literature DB >> 17569013

Evaluation of a novel nanocrystalline hydroxyapatite paste and a solid hydroxyapatite ceramic for the treatment of critical size bone defects (CSD) in rabbits.

Franz-Xaver Huber1, Irina Berger, Nicholas McArthur, Colette Huber, Hans-Peter Kock, Jürgen Hillmeier, Peter Jürgen Meeder.   

Abstract

The purpose of our study was to test the effectiveness of Ostim nanocrystalline hydroxyapatite paste and Cerabone ceramic by treating a critical size bone defect (CSD) on the right foreleg of a white New Zealand rabbit. Evaluation was carried out by comparing four groups each with a different CSD filling: an only OSTIM bone filling, an only Cerabone filling, an OSTIM-Cerabone combination, and a control group with no filling of the CSD. The results of this study display a rapid and uniform bone ingrowth following the CSD filling with Ostim. The histological and histomorphometrical data have shown similarly excellent results for both the Ostim and Cerabone-Ostim groups. The control group faired poorly in comparison, as three cases of non-union were observed and none of the defects were totally refilled with fresh bone within 60 days. The successful bone healing with osseous consolidation verifies the importance of the nanocrystalline hydroxyapatite in the treatment of metaphyseal osseous volume defects in the metaphyseal spongiosa.

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Year:  2007        PMID： 17569013     DOI： 10.1007/s10856-007-3039-0

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN： 0957-4530            Impact factor:   3.896


  43 in total

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  6 in total

1.  Histological evaluation of human intrabony periodontal defects treated with an unsintered nanocrystalline hydroxyapatite paste.

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Journal:  Clin Oral Investig       Date:  2012-05-03       Impact factor: 3.573

2.  Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro.

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Journal:  J Mater Sci Mater Med       Date:  2010-03-19       Impact factor: 3.896

3.  Evaluation of a novel nanocrystalline hydroxyapatite paste Ostim in comparison to Alpha-BSM - more bone ingrowth inside the implanted material with Ostim compared to Alpha BSM.

Authors:  Franz-Xaver Huber; Nicholas McArthur; Lydia Heimann; Elvira Dingeldein; Héloïse Cavey; Xavier Palazzi; Gaëlle Clermont; Jean-Pierre Boutrand
Journal:  BMC Musculoskelet Disord       Date:  2009-12-22       Impact factor: 2.362

4.  Nanocrystalline hydroxyapatite for bone repair: an animal study.

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Journal:  J Mater Sci Mater Med       Date:  2010-01       Impact factor: 3.896

5.  Comparison of Injectable Biphasic Calcium Phosphate and a Bovine Xenograft in Socket Preservation: Qualitative and Quantitative Histologic Study in Humans.

Authors:  Marija Čandrlić; Matej Tomas; Matej Karl; Lucija Malešić; Aleksandar Včev; Željka Perić Kačarević; Marko Matijević
Journal:  Int J Mol Sci       Date:  2022-02-25       Impact factor: 5.923

6.  Osseointegration at Implants Installed in Composite Bone: A Randomized Clinical Trial on Sinus Floor Elevation.

Authors:  Mitsuo Kotsu; Karol Alí Apaza Alccayhuaman; Mauro Ferri; Giovanna Iezzi; Adriano Piattelli; Natalia Fortich Mesa; Daniele Botticelli
Journal:  J Funct Biomater       Date:  2022-02-28
  6 in total

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