Literature DB >> 1756689

Analgesia by nefopam: does it act through serotonin?

D Marazziti1, A Rotondo, F Ambrogi, G B Cassano.   

Abstract

In an attempt to clarify the possible mode of action of nefopam, a new analgesic compound, the authors tested its effects on imipramine (IMI) binding to platelet membranes. The results showed that nefopam exerted a concentration-dependent inhibition of IMI binding, with a potency comparable to that of tricyclic antidepressants. This finding suggests a possible intervention of serotonergic mechanisms in nefopam-related analgesia.

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Year:  1991        PMID： 1756689

Source DB:  PubMed          Journal:  Drugs Exp Clin Res        ISSN： 0378-6501


  6 in total

1.  Identifying mechanism-of-action targets for drugs and probes.

Authors:  Elisabet Gregori-Puigjané; Vincent Setola; Jérôme Hert; Brenda A Crews; John J Irwin; Eugen Lounkine; Lawrence Marnett; Bryan L Roth; Brian K Shoichet
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-18       Impact factor: 11.205

2.  A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.

Authors:  Raymond Poon; Helen Hong; Xin Wei; James Pan; Benjamin A Alman
Journal:  PLoS One       Date:  2012-05-30       Impact factor: 3.240

3.  Development and statistical optimization of nefopam hydrochloride loaded nanospheres for neuropathic pain using Box-Behnken design.

Authors:  S Sukhbir; S Yashpal; A Sandeep
Journal:  Saudi Pharm J       Date:  2015-03-25       Impact factor: 4.330

4.  Intravenous Nefopam Reduces Postherpetic Neuralgia during the Titration of Oral Medications.

Authors:  Young Chan Joo; Eun Sung Ko; Jae Geun Cho; Young Min Ok; Gyu Yong Jung; Kyung Hoon Kim
Journal:  Korean J Pain       Date:  2013-12-31

5.  Spinal noradrenergic modulation and the role of the alpha-2 receptor in the antinociceptive effect of intrathecal nefopam in the formalin test.

Authors:  Shin Ho Jeong; Bong Ha Heo; Sun Hong Park; Woong Mo Kim; Hyung Gon Lee; Myung Ha Yoon; Jeong Il Choi
Journal:  Korean J Pain       Date:  2013-12-31

6.  The effect of modulated electro-hyperthermia on the pharmacokinetic properties of nefopam in healthy volunteers: A randomised, single-dose, crossover open-label study.

Authors:  Sun Young Lee; Min-Gul Kim
Journal:  Int J Hyperthermia       Date:  2015-10-28       Impact factor: 3.914
  6 in total

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