| Literature DB >> 17566579 |
Satoko Handa-Miya1, Bon Kimura, Hajime Takahashi, Miki Sato, Tatsuya Ishikawa, Kazunori Igarashi, Tateo Fujii.
Abstract
InlA is a surface protein participating in the entry of Listeria monocytogenes into mammalian non-phagocytic cells. PrfA is a positive regulatory factor that regulates the expression of a set of virulence genes. Recent studies revealed that some L. monocytogenes strains have a truncated form of these proteins because of nonsense mutations in their sequences, and these truncations contribute to the significant reduction in virulence of this pathogen. In this study, sequence analyses of inlA and prfA among L. monocytogenes isolated from ready-to-eat seafood revealed that only one out of 59 isolates had a nonsense-mutated inlA and all had non-mutated prfA. This indicated that these strains could be fully virulent based on the sizes of these proteins.Entities:
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Year: 2007 PMID： 17566579 DOI： 10.1016/j.ijfoodmicro.2007.05.003
Source DB: PubMed Journal: Int J Food Microbiol ISSN： 0168-1605 Impact factor: 5.277