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Literature DB >> 17566024

Pancreatic protease-activated receptors: friend and foe.

Fred Gorelick¹.

Abstract

Mesh：

Substances：
Receptor, PAR-2

Year: 2007 PMID： 17566024 PMCID： PMC1994359 DOI： 10.1136/gut.2006.111245

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

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15 in total

1. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion.

Authors: Vijay P Singh; Lakshmi Bhagat; Sarah Navina; Rifat Sharif; Rajinder K Dawra; Ashok K Saluja
Journal: Gut Date: 2006-11-17 Impact factor: 23.059

2. Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation.

Authors: G Scheele; G Adler; H Kern
Journal: Gastroenterology Date: 1987-02 Impact factor: 22.682

3. Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane.

Authors: H Y Gaisano; M P Lutz; J Leser; L Sheu; G Lynch; L Tang; Y Tamori; W S Trimble; A M Salapatek
Journal: J Clin Invest Date: 2001-12 Impact factor: 14.808

4. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell.

Authors: M S O'Konski; S J Pandol
Journal: J Clin Invest Date: 1990-11 Impact factor: 14.808

5. Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion.

Authors: Atsufumi Kawabata; Ryotaro Kuroda; Minoru Nishida; Nanae Nagata; Yuriko Sakaguchi; Naoyuki Kawao; Hiroyuki Nishikawa; Naoki Arizono; Kenzo Kawai
Journal: Life Sci Date: 2002-10-04 Impact factor: 5.037

1. Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis.

Authors: Cong Lin; Jan von der Thüsen; Joost Daalhuisen; Marieke ten Brink; Bruno Crestani; Tom van der Poll; Keren Borensztajn; C Arnold Spek
Journal: Mol Med Date: 2015-06-29 Impact factor: 6.354

1 in total

Pancreatic protease-activated receptors: friend and foe.

1. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion.

2. Exocytosis occurs at the lateral plasma membrane of the pancreatic acinar cell during supramaximal secretagogue stimulation.

3. Supramaximal cholecystokinin displaces Munc18c from the pancreatic acinar basal surface, redirecting apical exocytosis to the basal membrane.

4. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell.

5. Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion.

6. Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis.

7. Trypsin mediates nociception via the proteinase-activated receptor 2: a potentially novel role in pancreatic pain.

8. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury.

9. Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas.

10. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2.

1. Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis.