Literature DB >> 17566002

Outpatient parenteral antimicrobial therapy (OPAT): is it safe for selected patients to self-administer at home? A retrospective analysis of a large cohort over 13 years.

Philippa C Matthews1, Christopher P Conlon, Anthony R Berendt, Jill Kayley, Lorrayne Jefferies, Bridget L Atkins, Ivor Byren.   

Abstract

OBJECTIVES: Provision of outpatient parenteral antimicrobial therapy (OPAT) is an evolving field, facilitating discharge from hospital for selected patients with serious infections. We report on a large OPAT cohort focusing on the practice of supervised parenteral antibiotic administration in the community by patients and relatives, which we collectively term 'self-administration'. To distinguish between healthcare professional OPAT and self-administered OPAT, we have coined the terms H-OPAT and S-OPAT, respectively. PATIENTS AND METHODS: We analysed data on 2059 OPAT episodes collected prospectively over a 13 year time period from 1993 to 2005.
RESULTS: Clinical diagnosis, microbiology and antibiotics in this OPAT series are comparable to those previously reported. We identified no excess complications or hospital re-admissions in the S-OPAT group compared with the H-OPAT group.
CONCLUSIONS: Self-administration of intravenous antimicrobial therapy, in selected patients under the supervision of a specialist team, is a safe and feasible strategy.

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Year:  2007        PMID: 17566002     DOI: 10.1093/jac/dkm210

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN: 0305-7453            Impact factor:   5.790


  38 in total

1.  Safety and effectiveness of home intravenous antibiotic therapy for multidrug-resistant bacterial infections.

Authors:  A Mujal; J Sola; M Hernandez; M-A Villarino; M-L Machado; M Baylina; J Tajan; J Oristrell
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2.  Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach.

Authors:  A Vargas-Palacios; D M Meads; M Twiddy; C Czoski Murray; C Hulme; E D Mitchell; A Gregson; P Stanley; J Minton
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3.  Chronic osteomyelitis.

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4.  Outpatient parenteral antimicrobial therapy.

Authors:  Kevin B Laupland; Louis Valiquette
Journal:  Can J Infect Dis Med Microbiol       Date:  2013       Impact factor: 2.471

5.  The Impact of an Infectious Diseases Transition Service on the Care of Outpatients on Parenteral Antimicrobial Therapy.

Authors:  Sara C Keller; Danielle Ciuffetelli; Warren Bilker; Anne Norris; Daniel Timko; Alex Rosen; Jennifer S Myers; Janet Hines; Joshua Metlay
Journal:  J Pharm Technol       Date:  2013-10

6.  Patient satisfaction in an outpatient parenteral antimicrobial therapy (OPAT) unit practising predominantly self-administration of antibiotics with elastomeric pumps.

Authors:  L Saillen; L Arensdorff; E Moulin; R Voumard; C Cochet; N Boillat-Blanco; C Gardiol; S de Vallière
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-03-11       Impact factor: 3.267

7.  Factors associated with successful completion of outpatient parenteral antibiotic therapy in an area with a high prevalence of multidrug-resistant bacteria: 30-day hospital admission and mortality rates.

Authors:  Thais Cristina Garbelini Salles; Santiago Grau Cerrato; Tatiana Fiscina Santana; Eduardo Alexandrino Medeiros
Journal:  PLoS One       Date:  2020-11-18       Impact factor: 3.240

8.  Self-administered outpatient parenteral antimicrobial therapy: a report of three years experience in the Irish healthcare setting.

Authors:  J Kieran; A O'Reilly; J Parker; S Clarke; C Bergin
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2009-08-21       Impact factor: 3.267

9.  Outpatient parenteral antimicrobial therapy for surgery patients: A comparison with previous standard of care.

Authors:  Anjie Yang; Ron Fung; James Brunton; Linda Dresser
Journal:  Can J Infect Dis Med Microbiol       Date:  2013       Impact factor: 2.471

10.  Two-stage revision for prosthetic joint infection: predictors of outcome and the role of reimplantation microbiology.

Authors:  P Bejon; A Berendt; B L Atkins; N Green; H Parry; S Masters; P McLardy-Smith; R Gundle; I Byren
Journal:  J Antimicrob Chemother       Date:  2010-01-06       Impact factor: 5.790

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