PROBLEM: It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia. METHOD OF STUDY: We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies. RESULTS: IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity. CONCLUSION: Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.
PROBLEM: It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia. METHOD OF STUDY: We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies. RESULTS:IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity. CONCLUSION: Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.
Authors: Stephanie A Worton; Harry A T Pritchard; Susan L Greenwood; Mariam Alakrawi; Alexander E P Heazell; Mark Wareing; Adam Greenstein; Jenny E Myers Journal: Circ Res Date: 2021-03-03 Impact factor: 17.367
Authors: Mark K Santillan; Christopher J Pelham; Pimonrat Ketsawatsomkron; Donna A Santillan; Deborah R Davis; Eric J Devor; Katherine N Gibson-Corley; Sabrina M Scroggins; Justin L Grobe; Baoli Yang; Steven K Hunter; Curt D Sigmund Journal: Physiol Rep Date: 2015-01-19