OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs. METHODS: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10,036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles. RESULTS: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE epsilon 4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3; 95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals. CONCLUSIONS: Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.
OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs. METHODS: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10,036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles. RESULTS: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE epsilon 4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3; 95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals. CONCLUSIONS:Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.
Authors: Cecilia S Lee; Michael L Lee; Laura E Gibbons; Ryan T Yanagihara; Marian Blazes; Jason P Kam; Susan M McCurry; James D Bowen; Wayne C McCormick; Aaron Y Lee; Eric B Larson; Paul K Crane Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472
Authors: M Kamran Ikram; Xueling Sim; Sim Xueling; Richard A Jensen; Mary Frances Cotch; Alex W Hewitt; M Arfan Ikram; Jie Jin Wang; Ronald Klein; Barbara E K Klein; Monique M B Breteler; Ning Cheung; Gerald Liew; Paul Mitchell; Andre G Uitterlinden; Fernando Rivadeneira; Albert Hofman; Paulus T V M de Jong; Cornelia M van Duijn; Linda Kao; Ching-Yu Cheng; Albert Vernon Smith; Nicole L Glazer; Thomas Lumley; Barbara McKnight; Bruce M Psaty; Fridbert Jonasson; Gudny Eiriksdottir; Thor Aspelund; Tamara B Harris; Lenore J Launer; Kent D Taylor; Xiaohui Li; Sudha K Iyengar; Quansheng Xi; Theru A Sivakumaran; David A Mackey; Stuart Macgregor; Nicholas G Martin; Terri L Young; Josh C Bis; Kerri L Wiggins; Susan R Heckbert; Christopher J Hammond; Toby Andrew; Samantha Fahy; John Attia; Elizabeth G Holliday; Rodney J Scott; F M Amirul Islam; Jerome I Rotter; Annie K McAuley; Eric Boerwinkle; E Shyong Tai; Vilmundur Gudnason; David S Siscovick; Johannes R Vingerling; Tien Y Wong Journal: PLoS Genet Date: 2010-10-28 Impact factor: 5.917
Authors: Xueling Sim; Richard A Jensen; M Kamran Ikram; Mary Frances Cotch; Xiaohui Li; Stuart MacGregor; Jing Xie; Albert Vernon Smith; Eric Boerwinkle; Paul Mitchell; Ronald Klein; Barbara E K Klein; Nicole L Glazer; Thomas Lumley; Barbara McKnight; Bruce M Psaty; Paulus T V M de Jong; Albert Hofman; Fernando Rivadeneira; Andre G Uitterlinden; Cornelia M van Duijn; Thor Aspelund; Gudny Eiriksdottir; Tamara B Harris; Fridbert Jonasson; Lenore J Launer; John Attia; Paul N Baird; Stephen Harrap; Elizabeth G Holliday; Michael Inouye; Elena Rochtchina; Rodney J Scott; Ananth Viswanathan; Guo Li; Nicholas L Smith; Kerri L Wiggins; Jane Z Kuo; Kent D Taylor; Alex W Hewitt; Nicholas G Martin; Grant W Montgomery; Cong Sun; Terri L Young; David A Mackey; Natalie R van Zuydam; Alex S F Doney; Colin N A Palmer; Andrew D Morris; Jerome I Rotter; E Shyong Tai; Vilmundur Gudnason; Johannes R Vingerling; David S Siscovick; Jie Jin Wang; Tien Y Wong Journal: PLoS One Date: 2013-06-12 Impact factor: 3.240