Literature DB >> 17562799

Large-scale surveillance of Plasmodium falciparum crt(K76T) in northern Ghana.

Stephan Ehrhardt1, Teunis A Eggelte, Sarah Kaiser, Lydia Adjei, Gerd D Burchard, Sylvester D Anemana, Ulrich Bienzle, Frank P Mockenhaupt.   

Abstract

Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

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Year:  2007        PMID： 17562799      PMCID： PMC2043215          DOI： 10.1128/AAC.00179-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Chloroquine-treatment failure in northern Ghana: roles of pfcrt T76 and pfmdr1 Y86.

Authors:  F P Mockenhaupt; S Ehrhardt; T A Eggelte; P Agana-Nsiire; K Stollberg; A Mathieu; M Markert; R N Otchwemah; U Bienzle
Journal:  Ann Trop Med Parasitol       Date:  2005-12

2.  High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction.

Authors:  G Snounou; S Viriyakosol; X P Zhu; W Jarra; L Pinheiro; V E do Rosario; S Thaithong; K N Brown
Journal:  Mol Biochem Parasitol       Date:  1993-10       Impact factor: 1.759

3.  Field evaluation of the use of an ELISA to detect chloroquine and its metabolites in blood, urine and breast-milk.

Authors:  A M Witte; H J Klever; B J Brabin; T A Eggelte; H J Van der Kaay; M P Alpers
Journal:  Trans R Soc Trop Med Hyg       Date:  1990 Jul-Aug       Impact factor: 2.184

Review 4.  Fitness of drug-resistant malaria parasites.

Authors:  David Walliker; Paul Hunt; Hamza Babiker
Journal:  Acta Trop       Date:  2005-04-18       Impact factor: 3.112

5.  Antimalarial drug use among caregivers in Ghana.

Authors:  Benjamin K Abuaku; Kwadwo A Koram; Fred N Binka
Journal:  Afr Health Sci       Date:  2004-12       Impact factor: 0.927

6.  Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.

Authors:  Kwadwo A Koram; Benjamin Abuaku; Nancy Duah; Neils Quashie
Journal:  Acta Trop       Date:  2005-09       Impact factor: 3.112

7.  Efficacy of combination therapy with artesunate plus amodiaquine compared to monotherapy with chloroquine, amodiaquine or sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum in Afghanistan.

Authors:  Naeem Durrani; Toby Leslie; Sayed Rahim; Kate Graham; Fayaz Ahmad; Mark Rowland
Journal:  Trop Med Int Health       Date:  2005-06       Impact factor: 2.622

8.  Short report: association between chloroquine and amodiaquine resistance and allelic variation in the Plasmodium falciparum multiple drug resistance 1 gene and the chloroquine resistance transporter gene in isolates from the upper Nile in southern Sudan.

Authors:  Edwin O Ochong; Ingrid V F van den Broek; Kees Keus; Alexis Nzila
Journal:  Am J Trop Med Hyg       Date:  2003-08       Impact factor: 2.345

9.  Pricing, distribution, and use of antimalarial drugs.

Authors:  S D Foster
Journal:  Bull World Health Organ       Date:  1991       Impact factor: 9.408

10.  Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana.

Authors:  S Ehrhardt; F P Mockenhaupt; P Agana-Nsiire; A Mathieu; S D Anemana; K Stark; R N Otchwemah; U Bienzle
Journal:  Ann Trop Med Parasitol       Date:  2002-04
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  3 in total

1.  Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in Ghana.

Authors:  Md Tauqeer Alam; Dziedzom K de Souza; Sumiti Vinayak; Sean M Griffing; Amanda C Poe; Nancy O Duah; Anita Ghansah; Kwame Asamoa; Laurence Slutsker; Michael D Wilson; John W Barnwell; Venkatachalam Udhayakumar; Kwadwo A Koram
Journal:  J Infect Dis       Date:  2011-01-15       Impact factor: 5.226

Review 2.  Molecular surveillance of antimalarial partner drug resistance in sub-Saharan Africa: a spatial-temporal evidence mapping study.

Authors:  Hanna Y Ehrlich; Justin Jones; Sunil Parikh
Journal:  Lancet Microbe       Date:  2020-09-07

3.  Amodiaquine-artesunate vs artemether-lumefantrine for uncomplicated malaria in Ghanaian children: a randomized efficacy and safety trial with one year follow-up.

Authors:  George O Adjei; Jorgen A L Kurtzhals; Onike P Rodrigues; Michael Alifrangis; Lotte C G Hoegberg; Emmanuel D Kitcher; Ebenezer V Badoe; Roberta Lamptey; Bamenla Q Goka
Journal:  Malar J       Date:  2008-07-11       Impact factor: 2.979
  3 in total

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