OBJECTIVE: Depression occurs frequently in patients with both Alzheimer's disease (AD) and Parkinson's disease (PD), but there has been little comparison of depression symptoms in the two populations. METHOD: The 15-item Geriatric Depression Scale (GDS-15) was administered as a depression screening instrument to 232 AD patients and 266 PD specialty care patients with at most mild dementia. Logistic regression models were used to determine disease-specific associations with individual GDS-15 items, and factor analysis was used to assess GDS-15 factor structure in the two populations. RESULTS: Controlling for total GDS-15 score and other covariates, AD patients reported more dissatisfaction with life (p = 0.03) and memory problems (p < 0.001), while PD patients reported more fearfulness (p = 0.01), helplessness (p < 0.01), a preference to stay at home (p = 0.02), and diminished energy (p < 0.01). Three factors were generated in PD (explaining 55% of the total variance) and five in AD (explaining 59% of the total variance), and the two main factors generated in both populations related primarily to unhappiness and negative thoughts. CONCLUSIONS: The factor structure of the GDS-15 is similar in AD and PD patients with at most mild stage dementia, but between-group differences on 6 of the GDS-15 items suggests the non-specificity of certain items in the two populations. Copyright (c) 2007 John Wiley & Sons, Ltd.
OBJECTIVE:Depression occurs frequently in patients with both Alzheimer's disease (AD) and Parkinson's disease (PD), but there has been little comparison of depression symptoms in the two populations. METHOD: The 15-item Geriatric Depression Scale (GDS-15) was administered as a depression screening instrument to 232 ADpatients and 266 PD specialty care patients with at most mild dementia. Logistic regression models were used to determine disease-specific associations with individual GDS-15 items, and factor analysis was used to assess GDS-15 factor structure in the two populations. RESULTS: Controlling for total GDS-15 score and other covariates, ADpatients reported more dissatisfaction with life (p = 0.03) and memory problems (p < 0.001), while PDpatients reported more fearfulness (p = 0.01), helplessness (p < 0.01), a preference to stay at home (p = 0.02), and diminished energy (p < 0.01). Three factors were generated in PD (explaining 55% of the total variance) and five in AD (explaining 59% of the total variance), and the two main factors generated in both populations related primarily to unhappiness and negative thoughts. CONCLUSIONS: The factor structure of the GDS-15 is similar in AD and PDpatients with at most mild stage dementia, but between-group differences on 6 of the GDS-15 items suggests the non-specificity of certain items in the two populations. Copyright (c) 2007 John Wiley & Sons, Ltd.
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