STUDY OBJECTIVE: To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea. DESIGN: Randomized, double-blinded, 2-arm, sham-controlled, multicenter, long-term, intention-to-treat trial of CPAP therapy. SETTING:Sleep clinics and laboratories at 5 university medical centers and community-based hospitals. PATIENTS OR PARTICIPANTS: Target enrollment is 1100 randomly assigned subjects across 5 clinical centers. INTERVENTIONS:Active versus sham (subtherapeutic) CPAP. MEASUREMENTS AND RESULTS: A battery of conventional and novel tests designed to evaluate neurocognitive function, mood, sleepiness, and quality of life. CONCLUSIONS: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) is designed to study obstructive sleep apnea and test the effects of CPAP through a comprehensive, controlled, and long-term trial in a large sample of subjects with obstructive sleep apnea.
RCT Entities:
STUDY OBJECTIVE: To assess the size, time course, and durability of the effects of long-term continuous positive airway pressure (CPAP) therapy on neurocognitive function, mood, sleepiness, and quality of life in patients with obstructive sleep apnea. DESIGN: Randomized, double-blinded, 2-arm, sham-controlled, multicenter, long-term, intention-to-treat trial of CPAP therapy. SETTING: Sleep clinics and laboratories at 5 university medical centers and community-based hospitals. PATIENTS OR PARTICIPANTS: Target enrollment is 1100 randomly assigned subjects across 5 clinical centers. INTERVENTIONS: Active versus sham (subtherapeutic) CPAP. MEASUREMENTS AND RESULTS: A battery of conventional and novel tests designed to evaluate neurocognitive function, mood, sleepiness, and quality of life. CONCLUSIONS: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) is designed to study obstructive sleep apnea and test the effects of CPAP through a comprehensive, controlled, and long-term trial in a large sample of subjects with obstructive sleep apnea.
Authors: Eileen R Chasens; Charles W Atwood; Lora E Burke; Mary Korytkowski; Robert Stansbury; Patrick J Strollo; Susan M Sereika Journal: Contemp Clin Trials Date: 2018-12-02 Impact factor: 2.226
Authors: Stuart F Quan; Rohit Budhiraja; Denise P Clarke; James L Goodwin; Daniel J Gottlieb; Deborah A Nichols; Richard D Simon; Terry W Smith; James K Walsh; Clete A Kushida Journal: J Clin Sleep Med Date: 2013-10-15 Impact factor: 4.062
Authors: Devin L Brown; Craig S Anderson; Ronald D Chervin; Clete A Kushida; Daniel S Lewin; Beth A Malow; Susan Redline; Edward B Goldman Journal: J Clin Sleep Med Date: 2011-02-15 Impact factor: 4.062
Authors: Joshua C Felver-Gant; Amanda S Bruce; Molly Zimmerman; Lawrence H Sweet; Richard P Millman; Mark S Aloia Journal: J Clin Sleep Med Date: 2007-10-15 Impact factor: 4.062
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