| Literature DB >> 17561390 |
A M González-Zuloeta Ladd1, F Liu, M P W A Houben, A Arias Vásquez, C Siemes, A C J W Janssens, J W W Coebergh, A Hofman, J A M J L Janssen, B H Ch Stricker, C M van Duijn.
Abstract
IGF-I is an important growth factor for the mammary gland. We evaluated the relationship of the IGF-I CA(n) polymorphism with breast cancer risk in Caucasian postmenopausal women and performed a meta-analysis of published data. The IGF-I CA(n) polymorphism was genotyped in 4091 from the Rotterdam Study. A disease-free survival analysis was performed along with a meta-analysis of all available data on IGF-I CA(n) polymorphism and breast cancer risk. During follow-up 159 women were diagnosed with breast cancer. The disease-free survival analysis adjusted for age at entry, age at menopause, body mass index and waist hip ratio yielded a HR=0.97 (95% CI=0.59-1.58) for CA(19) non-carriers against carriers. The meta-analysis using the random-effects model gave a pooled OR of 1.26 (95% CI=0.95-1.82) for IGF-I CA(19) non-carriers versus CA(19) homozygous carriers. According to these results, the IGF-I CA(19) promoter polymorphism is not likely to predict the risk of breast cancer.Entities:
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Year: 2007 PMID： 17561390 DOI： 10.1016/j.ejca.2007.04.026
Source DB: PubMed Journal: Eur J Cancer ISSN： 0959-8049 Impact factor: 9.162