| Literature DB >> 17560785 |
Ingrid Pettersson1, Søren Ebdrup, Miroslav Havranek, Pavel Pihera, Marek Korínek, John P Mogensen, Claus B Jeppesen, Eva Johansson, Per Sauerberg.
Abstract
Structure based ligand design was used in order to design a partial agonist for the PPARdelta receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARdelta receptor in complex with compound 2 was determined in order to understand the structural changes which gave rise to the decrease in maximum activation.Entities:
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Year: 2007 PMID： 17560785 DOI： 10.1016/j.bmcl.2007.05.079
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823