| Literature DB >> 17560654 |
Massimo Cametti1, Ivo Piantanida, Mladen Zinić, Antonella Dalla Cort, Luigi Mandolini, Marko Marjanović, Marijeta Kralj.
Abstract
The Al(III)-salophen complex 1 exhibited strong spectroscopic changes specifically upon addition of polyG and GpG, while double stranded DNA and RNA, and single stranded polyA, polyU and polyC induced negligible spectral changes of 1. Titrations with mono-nucleotides yielded no spectroscopic changes, revealing that there must be at least two consecutive guanines in single stranded oligonucleotide structure for a measurable spectroscopic change of 1. Preliminary results show that 1 has moderate antiproliferative effect on a number of human tumour cell lines.Entities:
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Year: 2007 PMID： 17560654 DOI： 10.1016/j.jinorgbio.2007.04.014
Source DB: PubMed Journal: J Inorg Biochem ISSN： 0162-0134 Impact factor: 4.155