Literature DB >> 17560537

Exposing the complex III Qo semiquinone radical.

Haibo Zhang1, Artur Osyczka, P Leslie Dutton, Christopher C Moser.   

Abstract

Complex III Qo site semiquinone has been assigned pivotal roles in productive energy-conversion and destructive superoxide generation. After a 30-year search, a genetic heme bH knockout arrests this transient semiquinone EPR radical, revealing the natural engineering balance pitting energy-conserving, short-circuit minimizing, split electron transfer and catalytic speed against damaging oxygen reduction.

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Year:  2007        PMID： 17560537      PMCID： PMC3554237          DOI： 10.1016/j.bbabio.2007.04.004

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  27 in total

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Authors:  T A Link
Journal:  FEBS Lett       Date:  1997-07-28       Impact factor: 4.124

2.  Assignment of the histidine axial ligands to the cytochrome bH and cytochrome bL components of the bc1 complex from Rhodobacter sphaeroides by site-directed mutagenesis.

Authors:  C H Yun; A R Crofts; R B Gennis
Journal:  Biochemistry       Date:  1991-07-09       Impact factor: 3.162

3.  Simultaneous reduction of iron-sulfur protein and cytochrome b(L) during ubiquinol oxidation in cytochrome bc(1) complex.

Authors:  Jian Zhu; Tsuyoshi Egawa; Syun-Ru Yeh; Linda Yu; Chang-An Yu
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-13       Impact factor: 11.205

4.  pH dependence of the oxidation-reduction potential of cytochrome c2.

Authors:  G W Pettigrew; T E Meyer; R G Bartsch; M D Kamen
Journal:  Biochim Biophys Acta       Date:  1976-05-14

5.  Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria.

Authors:  J F Turrens; A Alexandre; A L Lehninger
Journal:  Arch Biochem Biophys       Date:  1985-03       Impact factor: 4.013

6.  Ubiquinone in Rhodopseudomonas sphaeroides. Some thermodynamic properties.

Authors:  K I Takamiya; P L Dutton
Journal:  Biochim Biophys Acta       Date:  1979-04-11

7.  Superoxide anion generation by the cytochrome bc1 complex.

Authors:  Jian Sun; Bernard L Trumpower
Journal:  Arch Biochem Biophys       Date:  2003-11-15       Impact factor: 4.013

8.  Characterisation of binding of the methoxyacrylate inhibitors to mitochondrial cytochrome c reductase.

Authors:  U Brandt; H Schägger; G von Jagow
Journal:  Eur J Biochem       Date:  1988-05-02

9.  Thermodynamic properties of the semiquinone and its binding site in the ubiquinol-cytochrome c (c2) oxidoreductase of respiratory and photosynthetic systems.

Authors:  D E Robertson; R C Prince; J R Bowyer; K Matsuura; P L Dutton; T Ohnishi
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

10.  Multiple Q-cycle bypass reactions at the Qo site of the cytochrome bc1 complex.

Authors:  Florian Muller; Antony R Crofts; David M Kramer
Journal:  Biochemistry       Date:  2002-06-25       Impact factor: 3.162
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  36 in total

1.  A caged, destabilized, free radical intermediate in the q-cycle.

Authors:  Preethi R Vennam; Nicholas Fisher; Matthew D Krzyaniak; David M Kramer; Michael K Bowman
Journal:  Chembiochem       Date:  2013-09-05       Impact factor: 3.164

Review 2.  Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Authors:  Xianghui Zou; Bianca A Ratti; Joseph Gerald O'Brien; Sueli O Lautenschlager; David R Gius; Marcelo G Bonini; Yueming Zhu
Journal:  J Bioenerg Biomembr       Date:  2017-06-14       Impact factor: 2.945

3.  Modifications of protein environment of the [2Fe-2S] cluster of the bc1 complex: effects on the biophysical properties of the rieske iron-sulfur protein and on the kinetics of the complex.

Authors:  Sangmoon Lhee; Derrick R J Kolling; Satish K Nair; Sergei A Dikanov; Antony R Crofts
Journal:  J Biol Chem       Date:  2009-12-20       Impact factor: 5.157

Review 4.  Molecular mechanisms of superoxide production by complex III: a bacterial versus human mitochondrial comparative case study.

Authors:  Pascal Lanciano; Bahia Khalfaoui-Hassani; Nur Selamoglu; Anna Ghelli; Michela Rugolo; Fevzi Daldal
Journal:  Biochim Biophys Acta       Date:  2013-03-28

5.  Reaction mechanism of superoxide generation during ubiquinol oxidation by the cytochrome bc1 complex.

Authors:  Ying Yin; Shaoqing Yang; Linda Yu; Chang-An Yu
Journal:  J Biol Chem       Date:  2010-04-06       Impact factor: 5.157

6.  An electronic bus bar lies in the core of cytochrome bc1.

Authors:  Monika Swierczek; Ewelina Cieluch; Marcin Sarewicz; Arkadiusz Borek; Christopher C Moser; P Leslie Dutton; Artur Osyczka
Journal:  Science       Date:  2010-07-23       Impact factor: 47.728

7.  Breaking the Q-cycle: finding new ways to study Qo through thermodynamic manipulations.

Authors:  Sarah E Chobot; Haibo Zhang; Christopher C Moser; P Leslie Dutton
Journal:  J Bioenerg Biomembr       Date:  2008-10-28       Impact factor: 2.945

8.  Effect of mutations of arginine 94 on proton pumping, electron transfer, and superoxide anion generation in cytochrome b of the bc1 complex from Rhodobacter sphaeroides.

Authors:  Yuan-Gang Qu; Fei Zhou; Linda Yu; Chang-An Yu
Journal:  J Biol Chem       Date:  2012-12-03       Impact factor: 5.157

Review 9.  Design and use of photoactive ruthenium complexes to study electron transfer within cytochrome bc1 and from cytochrome bc1 to cytochrome c.

Authors:  Francis Millett; Jeffrey Havens; Sany Rajagukguk; Bill Durham
Journal:  Biochim Biophys Acta       Date:  2012-09-15

10.  The rate-limiting step in the cytochrome bc1 complex (Ubiquinol-Cytochrome c Oxidoreductase) is not changed by inhibition of cytochrome b-dependent deprotonation: implications for the mechanism of ubiquinol oxidation at center P of the bc1 complex.

Authors:  Raul Covian; Bernard L Trumpower
Journal:  J Biol Chem       Date:  2009-03-26       Impact factor: 5.157
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