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Literature DB >> 17555842

Comparative genomics reveals novel biochemical pathways.

Jure Piskur¹, Klaus D Schnackerz, Gorm Andersen, Olof Björnberg.

Abstract

How well do we understand which enzymes are involved in the primary metabolism of the cell? A recent study using comparative genomics and postgenomics approaches revealed a novel pathway in the most studied organism, Escherichia coli. The analysis of a new operon consisting of seven previously uncharacterized genes thought to be involved in the degradation of nucleic acid precursors shows the impact of comparative genomics on the discovery of novel pathways and enzymes.

Entities: Gene Species

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Year: 2007 PMID： 17555842 DOI： 10.1016/j.tig.2007.05.007

Source DB: PubMed Journal: Trends Genet ISSN： 0168-9525 Impact factor: 11.639

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Cited

11 in total

Review 1. Gene expression profiling and the use of genome-scale in silico models of Escherichia coli for analysis: providing context for content.

Authors: Nathan E Lewis; Byung-Kwan Cho; Eric M Knight; Bernhard O Palsson
Journal: J Bacteriol Date: 2009-04-10 Impact factor: 3.490

2. Evolution of cyclic amidohydrolases: a highly diversified superfamily.

Authors: Matthieu Barba; Nicolas Glansdorff; Bernard Labedan
Journal: J Mol Evol Date: 2013-08-27 Impact factor: 2.395

3. The metabolism of histamine in the Drosophila optic lobe involves an ommatidial pathway: β-alanine recycles through the retina.

Authors: Janusz Borycz; Jolanta A Borycz; Tara N Edwards; Gabrielle L Boulianne; Ian A Meinertzhagen
Journal: J Exp Biol Date: 2012-04-15 Impact factor: 3.312

4. Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.

Authors: Stina Lundgren; Birgit Andersen; Jure Piskur; Doreen Dobritzsch
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2007-09-19

5. Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds.

Authors: Stefanie Cornelius; Sandra Witz; Hardy Rolletschek; Torsten Möhlmann
Journal: J Exp Bot Date: 2011-08-23 Impact factor: 6.992

6. Alteration in circulating metabolites during and after heat stress in the conscious rat: potential biomarkers of exposure and organ-specific injury.

Authors: Danielle L Ippolito; John A Lewis; Chenggang Yu; Lisa R Leon; Jonathan D Stallings
Journal: BMC Physiol Date: 2014-12-24

Comparative genomics reveals novel biochemical pathways.

Review 1. Gene expression profiling and the use of genome-scale in silico models of Escherichia coli for analysis: providing context for content.

2. Evolution of cyclic amidohydrolases: a highly diversified superfamily.

3. The metabolism of histamine in the Drosophila optic lobe involves an ommatidial pathway: β-alanine recycles through the retina.

4. Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster.

5. Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds.

6. Alteration in circulating metabolites during and after heat stress in the conscious rat: potential biomarkers of exposure and organ-specific injury.

7. A substrate ambiguous enzyme facilitates genome reduction in an intracellular symbiont.

8. Global transcriptional dynamics of diapause induction in non-blood-fed and blood-fed Aedes albopictus.

9. The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila.

Review 10. Integration of bioinformatics to biodegradation.