Literature DB >> 17555768

Stochastic Gompertz model of tumour cell growth.

C F Lo1.   

Abstract

In this communication, based upon the deterministic Gompertz law of cell growth, a stochastic model in tumour growth is proposed. This model takes account of both cell fission and mortality too. The corresponding density function of the size of the tumour cells obeys a functional Fokker--Planck equation which can be solved analytically. It is found that the density function exhibits an interesting "multi-peak" structure generated by cell fission as time evolves. Within this framework the action of therapy is also examined by simply incorporating a therapy term into the deterministic cell growth term.

Entities:  

Mesh:

Year:  2007        PMID: 17555768     DOI: 10.1016/j.jtbi.2007.04.024

Source DB:  PubMed          Journal:  J Theor Biol        ISSN: 0022-5193            Impact factor:   2.691


  2 in total

1.  Modeling the efficacy of trastuzumab-DM1, an antibody drug conjugate, in mice.

Authors:  Nelson L Jumbe; Yan Xin; Douglas D Leipold; Lisa Crocker; Debra Dugger; Elaine Mai; Mark X Sliwkowski; Paul J Fielder; Jay Tibbitts
Journal:  J Pharmacokinet Pharmacodyn       Date:  2010-04-28       Impact factor: 2.745

Review 2.  Origins, structures, and functions of circulating DNA in oncology.

Authors:  A R Thierry; S El Messaoudi; P B Gahan; P Anker; M Stroun
Journal:  Cancer Metastasis Rev       Date:  2016-09       Impact factor: 9.264

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.