| Literature DB >> 17555448 |
Gustaf Hedström1, Mattias Berglund, Daniel Molin, Marie Fischer, Gunnar Nilsson, Ulf Thunberg, Majlis Book, Christer Sundström, Richard Rosenquist, Göran Roos, Martin Erlanson, Rose-Marie Amini, Gunilla Enblad.
Abstract
Previous studies indicate that the inflammatory response in diffuse large B-cell lymphomas (DLBCL) is important for the clinical outcome. Mast cells are key regulators in this response; we investigated whether the number of tryptase-positive mast cells is correlated with clinical outcome. Patients with many mast cells had a significantly better event-free survival (EFS) compared to those with few mast cells (P < 0.03 in both germinal centre (GC) and non-GC DLBCL. This supports the idea that the infiltration of mast cells is a reflection of the host inflammatory response and is related to a favourable outcome.Entities:
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Year: 2007 PMID： 17555448 DOI： 10.1111/j.1365-2141.2007.06612.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998