| Literature DB >> 17555361 |
Fei Yang1, Peihua Xi, Li Yang, Jingbo Lan, Rugang Xie, Jingsong You.
Abstract
The dual Lewis acid/base catalytic system, generated from N-methylimidazole (NMI), (R)-1,1'-bi-2-naphthol [(R)-BINOL], and Ti(OiPr)4, effectively catalyzes the enantioselective alkynylation of aldehydes in the presence of Et2Zn in good yields and excellent enantioselectivities of up to 94% ee at room temperature. The mild reaction conditions make it possible to use functional alkynes in this asymmetric addition.Entities:
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Year: 2007 PMID： 17555361 DOI： 10.1021/jo0707535
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354