| Literature DB >> 17553417 |
Abstract
BACE initiates the production of beta-amyloid (Abeta), the likely cause of Alzheimer's disease (AD). In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Abeta generation.Entities:
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Year: 2007 PMID： 17553417 DOI： 10.1016/j.neuron.2007.05.018
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173