| Literature DB >> 17552550 |
Annette Dalrymple1, Edward J Wild, Richard Joubert, Kirupa Sathasivam, Maria Björkqvist, Asa Petersén, Graham S Jackson, Jeremy D Isaacs, Mark Kristiansen, Gillian P Bates, Blair R Leavitt, Geoff Keir, Malcolm Ward, Sarah J Tabrizi.
Abstract
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.Entities:
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Year: 2007 PMID： 17552550 DOI： 10.1021/pr0700753
Source DB: PubMed Journal: J Proteome Res ISSN： 1535-3893 Impact factor: 4.466