| Literature DB >> 17551209 |
Yoshihito Shiono1, Mio Tsuchinari, Keiko Shimanuki, Takeshi Miyajima, Tetsuya Murayama, Takuya Koseki, Hartmut Laatsch, Takayuki Funakoshi, Koji Takanami, Keitarou Suzuki.
Abstract
Two new cyclic lipopeptides, fusaristatins A (1) and B (2) were isolated from rice cultures of a Fusarium sp. YG-45 in the course of a screening of endophytic fungi. Their structures of 1 and 2 were determined by spectroscopic methods. 2 showed a moderate inhibitory effect on topoisomerases I (IC50: 73 microM) and II (IC50: 98 microM) without cleavable complexes. Furthermore, 1 and 2 showed the growth-inhibitory activity toward lung cancer cells LU 65 with IC50 values of 23 and 7 microM, respectively.Entities:
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Year: 2007 PMID： 17551209 DOI： 10.1038/ja.2007.39
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649