Literature DB >> 17551080

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls.

P F Chinnery1, C Mowbray, S K Patel, J L Elson, M Sampson, G A Hitman, M I McCarthy, A T Hattersley, M Walker.   

Abstract

Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogenic mutations of mitochondrial DNA (mtDNA) can cause diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising the possibility that genetic variants of mtDNA alter the risk of developing the disorder. Recent studies have produced conflicting results. By studying 897 UK cases of type 2 diabetes and 1010 population-matched controls, it is shown that European mtDNA haplogroups are unlikely to play a major role in the risk of developing the disorder.

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Year:  2007        PMID： 17551080      PMCID： PMC2740896          DOI： 10.1136/jmg.2007.048876

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  9 in total

1.  The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216T > C and m.4917A > G variants.

Authors:  D Crispim; L H Canani; J L Gross; B Tschiedel; K E P Souto; I Roisenberg
Journal:  Ann Hum Genet       Date:  2006-07       Impact factor: 1.670

2.  Comprehensive association testing of common mitochondrial DNA variation in metabolic disease.

Authors:  Richa Saxena; Paul I W de Bakker; Karyn Singer; Vamsi Mootha; Noel Burtt; Joel N Hirschhorn; Daniel Gaudet; Bo Isomaa; Mark J Daly; Leif Groop; Kristin G Ardlie; David Altshuler
Journal:  Am J Hum Genet       Date:  2006-05-24       Impact factor: 11.025

3.  The power to detect disease associations with mitochondrial DNA haplogroups.

Authors:  David C Samuels; Andrew D Carothers; Robin Horton; Patrick F Chinnery
Journal:  Am J Hum Genet       Date:  2006-02-17       Impact factor: 11.025

4.  Mitochondrial DNA and survival after sepsis: a prospective study.

Authors:  Simon V Baudouin; David Saunders; Watcharee Tiangyou; Joanna L Elson; Jayne Poynter; Angela Pyle; Sharon Keers; Douglass M Turnbull; Neil Howell; Patrick F Chinnery
Journal:  Lancet       Date:  2005-12-17       Impact factor: 79.321

5.  Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants.

Authors:  Raquel Moreno-Loshuertos; Rebeca Acín-Pérez; Patricio Fernández-Silva; Nieves Movilla; Acisclo Pérez-Martos; Santiago Rodriguez de Cordoba; M Esther Gallardo; José Antonio Enríquez
Journal:  Nat Genet       Date:  2006-10-01       Impact factor: 38.330

6.  Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes.

Authors:  P F Chinnery; H R Elliott; S Patel; C Lambert; S M Keers; S E Durham; M I McCarthy; G A Hitman; A T Hattersley; M Walker
Journal:  Lancet       Date:  2005-11-05       Impact factor: 79.321

7.  A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q.

Authors:  S Wiltshire; A T Hattersley; G A Hitman; M Walker; J C Levy; M Sampson; S O'Rahilly; T M Frayling; J I Bell; G M Lathrop; A Bennett; R Dhillon; C Fletcher; C J Groves; E Jones; P Prestwich; N Simecek; P V Rao; M Wishart; G F Bottazzo; R Foxon; S Howell; D Smedley; L R Cardon; S Menzel; M I McCarthy
Journal:  Am J Hum Genet       Date:  2001-08-01       Impact factor: 11.025

8.  Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study.

Authors:  Joanna Poulton; Jian'an Luan; Vincent Macaulay; Susie Hennings; Jo Mitchell; Nicholas J Wareham
Journal:  Hum Mol Genet       Date:  2002-06-15       Impact factor: 6.150

9.  Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484.

Authors:  A Torroni; M Petrozzi; L D'Urbano; D Sellitto; M Zeviani; F Carrara; C Carducci; V Leuzzi; V Carelli; P Barboni; A De Negri; R Scozzari
Journal:  Am J Hum Genet       Date:  1997-05       Impact factor: 11.025
  9 in total
  28 in total

1.  European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142.

Authors:  Todd Hulgan; Richard Haubrich; Sharon A Riddler; Pablo Tebas; Marylyn D Ritchie; Grace A McComsey; David W Haas; Jeffrey A Canter
Journal:  AIDS       Date:  2011-01-02       Impact factor: 4.177

2.  Family-based mitochondrial association study of traits related to type 2 diabetes and the metabolic syndrome in adolescents.

Authors:  E M Byrne; A F McRae; D L Duffy; Z Z Zhao; N G Martin; J B Whitfield; P M Visscher; G W Montgomery
Journal:  Diabetologia       Date:  2009-09-04       Impact factor: 10.122

Review 3.  Perspectives on pharmacogenomics of antiretroviral medications and HIV-associated comorbidities.

Authors:  David W Haas; Philip E Tarr
Journal:  Curr Opin HIV AIDS       Date:  2015-03       Impact factor: 4.283

4.  Genetics, environment, and diabetes-related end-stage renal disease in the Canary Islands.

Authors:  Ana M González; Benito M Maceira; Estefanía Pérez; Vicente M Cabrera; Alfonso J López; José M Larruga
Journal:  Genet Test Mol Biomarkers       Date:  2012-04-05

5.  Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study.

Authors:  Patrick F Chinnery; Hannah R Elliott; Anila Syed; Peter M Rothwell
Journal:  Lancet Neurol       Date:  2010-03-31       Impact factor: 44.182

6.  Mitochondrial haplogroups associated with Japanese Alzheimer's patients.

Authors:  Shigeru Takasaki
Journal:  J Bioenerg Biomembr       Date:  2009-10       Impact factor: 2.945

7.  Association of genetic variation in the mitochondrial genome with blood pressure and metabolic traits.

Authors:  Chunyu Liu; Qiong Yang; Shih-Jen Hwang; Fengzhu Sun; Andrew D Johnson; Orian S Shirihai; Ramachandran S Vasan; Daniel Levy; Faina Schwartz
Journal:  Hypertension       Date:  2012-09-04       Impact factor: 10.190

8.  African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.

Authors:  Jing Sun; Todd T Brown; Weiqun Tong; David Samuels; Phyllis Tien; Brahim Aissani; Bradley Aouizerat; Maria Villacres; Mark H Kuniholm; Deborah Gustafson; Katherine Michel; Mardge Cohen; Michael Schneider; Adaora A Adimora; Mohammed K Ali; Hector Bolivar; Todd Hulgan
Journal:  Clin Infect Dis       Date:  2020-11-05       Impact factor: 9.079

9.  Mitochondrial DNA haplogroup T is associated with coronary artery disease and diabetic retinopathy: a case control study.

Authors:  Barbara Kofler; Edith E Mueller; Waltraud Eder; Olaf Stanger; Richard Maier; Martin Weger; Anton Haas; Robert Winker; Otto Schmut; Bernhard Paulweber; Bernhard Iglseder; Wilfried Renner; Martina Wiesbauer; Irene Aigner; Danijela Santic; Franz A Zimmermann; Johannes A Mayr; Wolfgang Sperl
Journal:  BMC Med Genet       Date:  2009-04-21       Impact factor: 2.103

10.  Japanese Alzheimer's disease and other complex disorders diagnosis based on mitochondrial SNP haplogroups.

Authors:  Shigeru Takasaki
Journal:  Int J Alzheimers Dis       Date:  2012-07-17
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