Literature DB >> 17550864

Anti-interleukin 6 receptor antibody tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease.

Hiroshi Kawabata, Naohisa Tomosugi, Junya Kanda, Yasuhiro Tanaka, Kazuyuki Yoshizaki, Takashi Uchiyama.   

Abstract

We report two cases of multicentric Castleman's disease (MCD) whose serum hepcidin levels were rapidly down-regulated by administration of tocilizumab, an anti- interleukin 6 (IL-6) receptor antibody. Our results indicate that IL-6-induced hepcidin over-production may be involved in the pathophysiology of microcytic anemia commonly observed in this disease.

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Year:  2007        PMID： 17550864     DOI： 10.3324/haematol.10794

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  23 in total

Review 1.  Iron homeostasis and the inflammatory response.

Authors:  Marianne Wessling-Resnick
Journal:  Annu Rev Nutr       Date:  2010-08-21       Impact factor: 11.848

2.  Rescuing iron-overloaded macrophages by conservative relocation of the accumulated metal.

Authors:  Yang-Sung Sohn; Anna-Maria Mitterstiller; William Breuer; Guenter Weiss; Z Ioav Cabantchik
Journal:  Br J Pharmacol       Date:  2011-09       Impact factor: 8.739

Review 3.  The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis.

Authors:  Hiroshi Kawabata
Journal:  Int J Hematol       Date:  2017-11-13       Impact factor: 2.490

4.  Iron deficiency and infection.

Authors:  Vishal Kumar; V P Choudhry
Journal:  Indian J Pediatr       Date:  2010-06-29       Impact factor: 1.967

5.  Proinflammatory state, hepcidin, and anemia in older persons.

Authors:  Luigi Ferrucci; Richard D Semba; Jack M Guralnik; William B Ershler; Stefania Bandinelli; Kushang V Patel; Kai Sun; Richard C Woodman; Nancy C Andrews; Robert J Cotter; Tomas Ganz; Elizabeta Nemeth; Dan L Longo
Journal:  Blood       Date:  2010-01-15       Impact factor: 22.113

6.  Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist.

Authors:  Marcel van Deuren; Joyce J C Kroot; Dorine W Swinkels
Journal:  Haematologica       Date:  2009-07-16       Impact factor: 9.941

Review 7.  Iron sequestration and anemia of inflammation.

Authors:  Tomas Ganz; Elizabeta Nemeth
Journal:  Semin Hematol       Date:  2009-10       Impact factor: 3.851

Review 8.  Genetics of asthma susceptibility and severity.

Authors:  Rebecca E Slager; Gregory A Hawkins; Xingnan Li; Dirkje S Postma; Deborah A Meyers; Eugene R Bleecker
Journal:  Clin Chest Med       Date:  2012-07-07       Impact factor: 2.878

9.  Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias.

Authors:  Elizabeta Nemeth
Journal:  Adv Hematol       Date:  2009-12-24

10.  An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study.

Authors:  Sarah Cherian; David A Forbes; Angus G Cook; Frank M Sanfilippo; Erwin H Kemna; Dorine W Swinkels; David P Burgner
Journal:  PLoS One       Date:  2008-12-24       Impact factor: 3.240
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