Literature DB >> 17550776

TXNIP links redox circuitry to glucose control.

Deborah M Muoio1.   

Abstract

Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A new study (Parikh et al., 2007) implicates this redox rheostat as a negative regulator of peripheral glucose metabolism in humans. Investigators combined human physiology, genomic screening, and cell-based genetic studies to highlight TNXIP as a potential culprit in the pathogenesis of type 2 diabetes.

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Year:  2007        PMID： 17550776     DOI： 10.1016/j.cmet.2007.05.011

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  42 in total

Review 1.  Physiological insights gained from gene expression analysis in obesity and diabetes.

Authors:  Mark P Keller; Alan D Attie
Journal:  Annu Rev Nutr       Date:  2010-08-21       Impact factor: 11.848

2.  Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet.

Authors:  Islam N Mohamed; Sherif S Hafez; Arwa Fairaq; Adviye Ergul; John D Imig; Azza B El-Remessy
Journal:  Diabetologia       Date:  2013-11-08       Impact factor: 10.122

3.  Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice.

Authors:  Chang Hyun Byon; Tieyan Han; Judy Wu; Simon T Hui
Journal:  Atherosclerosis       Date:  2015-06-03       Impact factor: 5.162

4.  Carbohydrate response element-binding protein (ChREBP) plays a pivotal role in beta cell glucotoxicity.

Authors:  N Poungvarin; J K Lee; V K Yechoor; M V Li; T Assavapokee; P Suksaranjit; J J Thepsongwajja; P K Saha; K Oka; L Chan
Journal:  Diabetologia       Date:  2012-03-03       Impact factor: 10.122

5.  Adaptive metabolic response to 4 weeks of sugar-sweetened beverage consumption in healthy, lightly active individuals and chronic high glucose availability in primary human myotubes.

Authors:  Francesco Sartor; Matthew J Jackson; Cesare Squillace; Anthony Shepherd; Jonathan P Moore; Donald E Ayer; Hans-Peter Kubis
Journal:  Eur J Nutr       Date:  2012-06-26       Impact factor: 5.614

6.  MondoA deficiency enhances sprint performance in mice.

Authors:  Minako Imamura; Benny Hung-Junn Chang; Motoyuki Kohjima; Ming Li; Byounghoon Hwang; Heinrich Taegtmeyer; Robert A Harris; Lawrence Chan
Journal:  Biochem J       Date:  2014-11-15       Impact factor: 3.857

7.  Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.

Authors:  Carrie A Stoltzman; Christopher W Peterson; Kevin T Breen; Deborah M Muoio; Andrew N Billin; Donald E Ayer
Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-05       Impact factor: 11.205

8.  Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules.

Authors:  Fa-Xing Yu; Yan Luo
Journal:  PLoS One       Date:  2009-12-22       Impact factor: 3.240

9.  Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.

Authors:  Cristina Cadenas; Dennis Franckenstein; Marcus Schmidt; Mathias Gehrmann; Matthias Hermes; Bettina Geppert; Wiebke Schormann; Lindsey J Maccoux; Markus Schug; Anika Schumann; Christian Wilhelm; Evgenia Freis; Katja Ickstadt; Jörg Rahnenführer; Jörg I Baumbach; Albert Sickmann; Jan G Hengstler
Journal:  Breast Cancer Res       Date:  2010-06-28       Impact factor: 6.466

10.  Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.

Authors:  Julia Ling-Yu Chen; Daniel Merl; Christopher W Peterson; Jianli Wu; Patrick Yantyng Liu; Hanwei Yin; Deborah M Muoio; Don E Ayer; Mike West; Jen-Tsan Chi
Journal:  PLoS Genet       Date:  2010-09-02       Impact factor: 5.917
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