| Literature DB >> 17550773 |
Abstract
A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism (Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARalpha transcription factor, is a "missing link" in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.Entities:
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Year: 2007 PMID： 17550773 DOI： 10.1016/j.cmet.2007.05.010
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287