FeSO4 x 7H2O-catalyzed four-component synthesis of protected homoallylic amines.

An efficient catalytic four-component reaction of carbonyl compounds (or acetals/ketals), benzyl chloroformate (CbzCl), 1,1,1,3,3,3-hexamethyldisilazane (HMDS), and allyltrimethylsilane has been successfully developed to produce Cbz-protected homoallylic amines in the presence of 5 mol % of iron(II) sulfate heptahydrate (FeSO4 x 7H2O), an inexpensive and environmentally friendly catalyst, at room temperature.