OBJECTIVE: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. METHODS: We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.
OBJECTIVE: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. METHODS: We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. RESULTS: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. CONCLUSION: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.
Authors: Russell H Tobe; Ravi Bansal; Dongrong Xu; Xuejun Hao; Jun Liu; Juan Sanchez; Bradley S Peterson Journal: Ann Neurol Date: 2010-04 Impact factor: 10.422
Authors: Alicja Lerner; Anto Bagic; Takashi Hanakawa; Eilis A Boudreau; Fernando Pagan; Zoltan Mari; William Bara-Jimenez; Murat Aksu; Susumu Sato; Dennis L Murphy; Mark Hallett Journal: Cereb Cortex Date: 2008-05-09 Impact factor: 5.357
Authors: Sule Tinaz; Beth A Belluscio; Patrick Malone; Jan Willem van der Veen; Mark Hallett; Silvina G Horovitz Journal: Hum Brain Mapp Date: 2014-07-15 Impact factor: 5.038