Literature DB >> 17548198

Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres.

François Liger1, Florence Popowycz, Thierry Besson, Laurent Picot, Carlos M Galmarini, Benoît Joseph.   

Abstract

Aza-analogues of clausine E, mukonine and koenoline were prepared from 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde and their antiproliferative activity was evaluated against miscellaneous cancer cell lines and compared to those obtained with clausine E and mukonine.

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Year:  2007        PMID: 17548198     DOI: 10.1016/j.bmc.2007.05.033

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  1 in total

1.  The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest.

Authors:  Suvitha Syam; Ahmad Bustamam Abdul; Mohd Aspollah Sukari; Syam Mohan; Siddig Ibrahim Abdelwahab; Tang Sook Wah
Journal:  Molecules       Date:  2011-08-23       Impact factor: 4.411

  1 in total

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