Literature DB >> 17548194

Synthesis of marine alkaloid: 8,9-dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents.

Leena Gupta1, Archna Talwar, Shraddha Palne, Suman Gupta, Prem M S Chauhan.   

Abstract

A series of marine alkaloid 8,9-dihydrocoscinamide B, its analogues and indolylglyoxylamide derivatives have been synthesized and screened for their in vitro antileishmanial activity profile in promastigote and amastigote models. Compounds 7 and 10 have shown 99-100% inhibition against promastigotes and 97-98% inhibition against amastigotes at a concentration of 10 microg/ml.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17548194     DOI： 10.1016/j.bmcl.2007.04.035

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Antileishmanial efficacy of fluconazole and miltefosine in combination with an immunomodulator--picroliv.

Authors:  Nishi Shakya; Shraddha A Sane; Suman Gupta
Journal:  Parasitol Res       Date:  2011-01-07       Impact factor: 2.289

2.  Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

Authors:  Roya Zoraghi; Liam Worrall; Raymond H See; Wendy Strangman; Wendy L Popplewell; Huansheng Gong; Toufiek Samaai; Richard D Swayze; Sukhbir Kaur; Marija Vuckovic; B Brett Finlay; Robert C Brunham; William R McMaster; Michael T Davies-Coleman; Natalie C Strynadka; Raymond J Andersen; Neil E Reiner
Journal:  J Biol Chem       Date:  2011-10-26       Impact factor: 5.157

3.  In vitro activities of new 2-substituted quinolines against Leishmania donovani.

Authors:  Philippe M Loiseau; Suman Gupta; Aditya Verma; Saumya Srivastava; S K Puri; Faten Sliman; Marie Normand-Bayle; Didier Desmaele
Journal:  Antimicrob Agents Chemother       Date:  2011-01-10       Impact factor: 5.191

4.  Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities.

Authors:  Mukund P Tantak; Vishakha Gupta; Kumar Nikhil; V Arun; Rajnish Prakash Singh; Prabhat Nath Jha; Kavita Shah; Dalip Kumar
Journal:  Bioorg Med Chem Lett       Date:  2016-04-28       Impact factor: 2.823

Review 5.  Visceral leishmaniasis: experimental models for drug discovery.

Authors:  Suman Gupta
Journal:  Indian J Med Res       Date:  2011-01       Impact factor: 2.375

Review 6.  Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria.

Authors:  Andre G Tempone; Pauline Pieper; Samanta E T Borborema; Fernanda Thevenard; Joao Henrique G Lago; Simon L Croft; Edward A Anderson
Journal:  Nat Prod Rep       Date:  2021-12-15       Impact factor: 13.423
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.