OBJECTIVE: Adiponectin is an adipocyte-derived, antiatherogenic protein that is present in plasma as a large multimeric structure of high molecular weight (HMW) and in a trimer or hexamer form (non-HMW). The biological activities of these isoforms have not yet been elucidated. We therefore examined the effect of these isoforms on endothelial function in healthy young men. DESIGN: One hundred apparently healthy young men without overt cardiovascular disease (mean age 30 years) were recruited in this cross-sectional study based on voluntary enrollment. MEASUREMENTS: We evaluated endothelial function estimated by flow-mediated dilatation (FMD) of the brachial artery during reactive hyperaemia, and measured total and HMW adiponectin levels. RESULTS: Both HMW and non-HMW adiponectin levels showed a significant, inverse correlation with body mass index (BMI). FMD was significantly correlated with fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), malondialdehyde-modified low density lipoprotein (MDA-LDL), LDL particle size, and HMW adiponectin (r = 0.320, P = 0.001), but not non-HMW adiponectin (r = 0.125, P = 0.22). In multivariate analysis, HMW adiponectin and MDA-LDL were selected as independent factors capable of influencing FMD. No variables determined nitroglycerin-induced dilatation. CONCLUSIONS: These results suggest that even in young men, plasma adiponectin levels can predict endothelial dysfunction before any overt vascular disease has occurred. HMW adiponectin may be more useful as a marker of endothelial dysfunction than total adiponectin.
OBJECTIVE:Adiponectin is an adipocyte-derived, antiatherogenic protein that is present in plasma as a large multimeric structure of high molecular weight (HMW) and in a trimer or hexamer form (non-HMW). The biological activities of these isoforms have not yet been elucidated. We therefore examined the effect of these isoforms on endothelial function in healthy young men. DESIGN: One hundred apparently healthy young men without overt cardiovascular disease (mean age 30 years) were recruited in this cross-sectional study based on voluntary enrollment. MEASUREMENTS: We evaluated endothelial function estimated by flow-mediated dilatation (FMD) of the brachial artery during reactive hyperaemia, and measured total and HMW adiponectin levels. RESULTS: Both HMW and non-HMW adiponectin levels showed a significant, inverse correlation with body mass index (BMI). FMD was significantly correlated with fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), malondialdehyde-modified low density lipoprotein (MDA-LDL), LDL particle size, and HMW adiponectin (r = 0.320, P = 0.001), but not non-HMW adiponectin (r = 0.125, P = 0.22). In multivariate analysis, HMW adiponectin and MDA-LDL were selected as independent factors capable of influencing FMD. No variables determined nitroglycerin-induced dilatation. CONCLUSIONS: These results suggest that even in young men, plasma adiponectin levels can predict endothelial dysfunction before any overt vascular disease has occurred. HMW adiponectin may be more useful as a marker of endothelial dysfunction than total adiponectin.
Authors: Zhongjie Fu; Chatarina A Lofqvist; Zhuo Shao; Ye Sun; Jean-Sebastien Joyal; Christian G Hurst; Ricky Z Cui; Lucy P Evans; Katherine Tian; John Paul SanGiovanni; Jing Chen; David Ley; Ingrid Hansen Pupp; Ann Hellstrom; Lois E H Smith Journal: Am J Clin Nutr Date: 2015-02-04 Impact factor: 7.045
Authors: Nisha I Parikh; Michelle J Keyes; Martin G Larson; Karla M Pou; Naomi M Hamburg; Joseph A Vita; Christopher J O'Donnell; Ramachandran S Vasan; Gary F Mitchell; Udo Hoffmann; Caroline S Fox; Emelia J Benjamin Journal: Obesity (Silver Spring) Date: 2009-03-12 Impact factor: 5.002