OBJECTIVE: To review the literature on the interaction between sleep and the immune system. METHOD: A search on Web of Science and Pubmed database including the keywords sleep, sleep deprivation, stress, hypothalamic-pituitary-adrenal axis, immune system, and autoimmune diseases. RESULTS: On Web of Science, 588 publications were retrieved; 61 references, more significant and closer to our objective, were used, including original articles and review papers. CONCLUSION: Sleep deprivation and immune system exert a bidirectional influence on each other. Since sleep deprivation is considered a stressor, inasmuch as it induces elevation of cortisol or corticosterone levels in humans and rodents, respectively, and given the well-known immunosuppressive effect of glucocorticoids, we propose that increased activation of the hypothalamic-pituitary-adrenal axis is a major mediator of the immune alterations observed in patients with insomnia or in sleep deprived subjects.
OBJECTIVE: To review the literature on the interaction between sleep and the immune system. METHOD: A search on Web of Science and Pubmed database including the keywords sleep, sleep deprivation, stress, hypothalamic-pituitary-adrenal axis, immune system, and autoimmune diseases. RESULTS: On Web of Science, 588 publications were retrieved; 61 references, more significant and closer to our objective, were used, including original articles and review papers. CONCLUSION:Sleep deprivation and immune system exert a bidirectional influence on each other. Since sleep deprivation is considered a stressor, inasmuch as it induces elevation of cortisol or corticosterone levels in humans and rodents, respectively, and given the well-known immunosuppressive effect of glucocorticoids, we propose that increased activation of the hypothalamic-pituitary-adrenal axis is a major mediator of the immune alterations observed in patients with insomnia or in sleep deprived subjects.
Authors: Kristyn M Ringgold; R Paulien Barf; Amrita George; Blair C Sutton; Mark R Opp Journal: J Neurosci Methods Date: 2013-07-16 Impact factor: 2.390
Authors: Elizabeth G Ibarra-Coronado; Javier Velazquéz-Moctezuma; Daniel Diaz; Luis Enrique Becerril-Villanueva; Lenin Pavón; Jorge Morales-Montor Journal: Int J Biol Sci Date: 2015-06-06 Impact factor: 6.580
Authors: Giuliana Travassos Pires Santiago; Ana Cecília de Menezes Galvão; Raíssa Nóbrega de Almeida; Sergio Arthuro Mota-Rolim; Fernanda Palhano-Fontes; João Paulo Maia-de-Oliveira; Dráulio Barros de Araújo; Bruno Lobão-Soares; Nicole Leite Galvão-Coelho Journal: Front Behav Neurosci Date: 2020-04-28 Impact factor: 3.558