OBJECTIVE: Systematic assessment of the in vitro research on high potency effects. METHOD: Publications of experiments were collected through databases, experts, previous reviews, citation tracking. INCLUSION CRITERIA: stepwise agitated dilutions <10(-23); cells or molecules from human or animal. Experiments were assessed with the modified SAPEH score. RESULTS: From 75 publications, 67 experiments (1/3 of them replications) were evaluated. Nearly 3/4 of them found a high potency effect, and 2/3 of those 18 that scored 6 points or more and controlled contamination. Nearly 3/4 of all replications were positive. Design and experimental models of the reviewed experiments were inhomogenous, most were performed on basophiles. CONCLUSIONS: Even experiments with a high methodological standard could demonstrate an effect of high potencies. No positive result was stable enough to be reproduced by all investigators. A general adoption of succussed controls, randomization and blinding would strengthen the evidence of future experiments.
OBJECTIVE: Systematic assessment of the in vitro research on high potency effects. METHOD: Publications of experiments were collected through databases, experts, previous reviews, citation tracking. INCLUSION CRITERIA: stepwise agitated dilutions <10(-23); cells or molecules from human or animal. Experiments were assessed with the modified SAPEH score. RESULTS: From 75 publications, 67 experiments (1/3 of them replications) were evaluated. Nearly 3/4 of them found a high potency effect, and 2/3 of those 18 that scored 6 points or more and controlled contamination. Nearly 3/4 of all replications were positive. Design and experimental models of the reviewed experiments were inhomogenous, most were performed on basophiles. CONCLUSIONS: Even experiments with a high methodological standard could demonstrate an effect of high potencies. No positive result was stable enough to be reproduced by all investigators. A general adoption of succussed controls, randomization and blinding would strengthen the evidence of future experiments.
Authors: Harald J Hamre; Claudia M Witt; Gunver S Kienle; Christoph Meinecke; Anja Glockmann; Renatus Ziegler; Stefan N Willich; Helmut Kiene Journal: Int J Gen Med Date: 2010-08-30
Authors: Caroline Eyles; Geraldine M Leydon; George T Lewith; Sarah Brien Journal: Evid Based Complement Alternat Med Date: 2010-09-30 Impact factor: 2.629
Authors: B Stock-Schröer; H Albrecht; L Betti; G Dobos; C Endler; K Linde; R Lüdtke; F Musial; R van Wijk; C Witt; S Baumgartner Journal: Evid Based Complement Alternat Med Date: 2011-03-10 Impact factor: 2.629
Authors: Sabine D Klein; Annegret Sandig; Stephan Baumgartner; Ursula Wolf Journal: Evid Based Complement Alternat Med Date: 2013-01-15 Impact factor: 2.629