| Literature DB >> 17544373 |
Keiki Sugimoto1, Hidenori Kage, Naomi Aki, Atsushi Sano, Hiroshi Kitagawa, Takahide Nagase, Yutaka Yatomi, Nobuya Ohishi, Daiya Takai.
Abstract
The field of epigenetics has made progress by the identification of the small RNA-mediated epigenetic modification. However, little is known about the key proteins. Here, we report that the human PIWI-like family is a candidate protein that is involved in the pathway responsible for chromatin remodeling. The PIWI-like family proteins, expressed as the Flag-fusion proteins, formed a bulky body and localized to the nuclear periphery. Transient transfection of PIWI-like 4 (PIWIL4), only member of the PIWI-like family that was ubiquitously expressed in human tissues, induced histone H3 lysine 9 methylation at the p16(Ink4a) (CDKN2A) locus. The elevated level of histone methylation resulted in the downregulation of the p16(Ink4a) gene. These results suggest PIWIL4 plays important roles in the chromatin-modifying pathway in human somatic cells.Entities:
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Year: 2007 PMID： 17544373 DOI： 10.1016/j.bbrc.2007.05.136
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575