| Literature DB >> 17544272 |
Imadul Islam1, Greg Brown, Judi Bryant, Paul Hrvatin, Monica J Kochanny, Gary B Phillips, Shendong Yuan, Marc Adler, Marc Whitlow, Dao Lentz, Mark A Polokoff, James Wu, Jun Shen, Janette Walters, Elena Ho, Babu Subramanyam, Daguang Zhu, Richard I Feldman, Damian O Arnaiz.
Abstract
Based on the lead compound BX-517, a series of C-4' substituted indolinones have been synthesized and evaluated for PDK1 inhibition. Modification at C-4' of the pyrrole afforded potent compounds (7b and 7d) with improved solubility and ADME properties. In this letter, we describe the synthesis, selectivity profile, and pharmacokinetic data of selected compounds.Entities:
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Year: 2007 PMID： 17544272 DOI： 10.1016/j.bmcl.2007.05.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823