Literature DB >> 17544171

Regeneration-based therapies for spinal cord injuries.

Hideyuki Okano1, Shinjiro Kaneko, Seiji Okada, Akio Iwanami, Masaya Nakamura, Yoshiaki Toyama.   

Abstract

Although it has been long believed that the damaged central nervous system does not regenerate upon injury, there is an emerging hope for regeneration-based therapy of the damaged central nervous system (CNS) due to the progress of developmental biology and regenerative medicine including stem cell biology. In this review, we have summarized recent studies aimed at the development of regeneration-based therapeutic approaches for spinal cord injuries, including therapy with anti-inflammatory cytokines, transplantation of neural stem/precursor cells and induction of axonal regeneration.

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Year:  2007        PMID： 17544171     DOI： 10.1016/j.neuint.2007.04.013

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  6 in total

Review 1.  Scar-modulating treatments for central nervous system injury.

Authors:  Dingding Shen; Xiaodong Wang; Xiaosong Gu
Journal:  Neurosci Bull       Date:  2014-06-24       Impact factor: 5.203

2.  Clinical outcomes of late decompression surgery following cervical spinal cord injury with pre-existing cord compression.

Authors:  Tsunehiko Konomi; Akimasa Yasuda; Kanehiro Fujiyoshi; Junichi Yamane; Shinjiro Kaneko; Takatsugu Komiyama; Masakazu Takemitsu; Yoshiyuki Yato; Osahiko Tsuji; Morio Matsumoto; Masaya Nakamura; Takashi Asazuma
Journal:  Spinal Cord       Date:  2017-12-19       Impact factor: 2.772

3.  Glial restricted precursors maintain their permissive properties after long-term expansion but not following exposure to pro-inflammatory factors.

Authors:  Kazuo Hayakawa; Christopher Haas; Ying Jin; Julien Bouyer; Takanobu Otsuka; Itzhak Fischer
Journal:  Brain Res       Date:  2015-10-21       Impact factor: 3.252

Review 4.  Neural stem cells and strategies for the regeneration of the central nervous system.

Authors:  Hideyuki Okano
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

5.  Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model.

Authors:  Desirée L Salazar; Nobuko Uchida; Frank P T Hamers; Brian J Cummings; Aileen J Anderson
Journal:  PLoS One       Date:  2010-08-18       Impact factor: 3.240

6.  Intravenous injection of neural progenitor cells improved depression-like behavior after cerebral ischemia.

Authors:  Y Moriyama; N Takagi; K Tanonaka
Journal:  Transl Psychiatry       Date:  2011-08-09       Impact factor: 6.222
  6 in total

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