Literature DB >> 17543533

Normal platelet mitochondrial complex I activity in Huntington's disease.

William J Powers1, Richard H Haas, Thuy Le, Tom O Videen, Tamara Hershey, Lori McGee-Minnich, Joel S Perlmutter.   

Abstract

Two small case series of platelet mitochondrial complex I activity assays in Huntington's Disease (HD) report discrepant results. We measured platelet complex I and complex I/III activity in 21 subjects with early gene-positive HD and 14 age-matched controls. The 21 participants with HD that we studied are greater than the total of 16 in the two previously published of platelet ETS activity in HD. Reductions > 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present.

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Year:  2007        PMID： 17543533      PMCID： PMC2140002          DOI： 10.1016/j.nbd.2007.04.008

Source DB:  PubMed          Journal:  Neurobiol Dis        ISSN： 0969-9961            Impact factor:   5.996


  10 in total

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