Characterization of the retention behavior of organic and pharmaceutical drug molecules on an immobilized artificial membrane column with the Abraham model.

Data have been compiled from the published literature on the retention factors of 174 organic compounds and drug molecules eluted from a Regis Technologies IAM.PC.DD2 HPLC column using an aqueous mobile phase buffered in the pH range of pH 6.5-7.5. The logarithms of the retention factors are correlated with the Abraham solvation parameter model. The derived correlation contains the five Abraham solute descriptors plus two additional indicator descriptors (I(COOH) and I(amine)) that would be needed whenever carboxylic acid and alkylamine solutes are eluted in ionic form. The derived correlation describes the experimental capacity data of 174 neutral, acidic and basic compounds to within 0.21 log units.