Shi-hai Xia1, Dian-chun Fang. 1. Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 40038, China.
Abstract
OBJECTIVE: To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating factor", and "pharmacological". Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected. RESULTS: The key issues related to the pharmacological actions and mechanisms of ginkgolide B were summarized. The ginkgolide B possesses a number of beneficial effects such as anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects. Meantime, their mechaniams were discussed. CONCLUSIONS: The Ginkgolide B is the most potent antagonist of platelet activating factor (PAF) and exhibits therapeutic action in a variety of diseases mainly by the PAF receptor.
OBJECTIVE: To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "platelet activating factor", and "pharmacological". Study selection Mainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected. RESULTS: The key issues related to the pharmacological actions and mechanisms of ginkgolide B were summarized. The ginkgolide B possesses a number of beneficial effects such as anti-inflammatory, anti-allergic, antioxidant, and neuroprotective effects. Meantime, their mechaniams were discussed. CONCLUSIONS: The Ginkgolide B is the most potent antagonist of platelet activating factor (PAF) and exhibits therapeutic action in a variety of diseases mainly by the PAF receptor.
Authors: Zhao-Ma Shu; Xiao-Dong Shu; Hui-Qin Li; Yi Sun; Han Shan; Xi-Yang Sun; Ren-Hong Du; Ming Lu; Ming Xiao; Jian-Hua Ding; Gang Hu Journal: CNS Neurosci Ther Date: 2016-06-16 Impact factor: 5.243