Literature DB >> 17542953

Amygdala dysfunction in narcolepsy-cataplexy.

Ramin Khatami1, Steffen Birkmann, Claudio L Bassetti.   

Abstract

The blink reflex of acoustic startle reflex (ASR) is modulated by emotions and a loss of physiological aversive ASR potentiation is reported in humans following amygdala lesions. Patients with narcolepsy-cataplexy (NC) were found to have normal ASR, but they failed to exhibit startle potentiation during unpleasant stimuli. This absence of aversive ASR potentiation gives support to the hypothesis of an amygdala dysfunction in human NC.

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Year:  2007        PMID: 17542953     DOI: 10.1111/j.1365-2869.2007.00587.x

Source DB:  PubMed          Journal:  J Sleep Res        ISSN: 0962-1105            Impact factor:   3.981


  9 in total

1.  The brain orexin system and almorexant in fear-conditioned startle reactions in the rat.

Authors:  Michel A Steiner; Hugues Lecourt; Francois Jenck
Journal:  Psychopharmacology (Berl)       Date:  2012-05-17       Impact factor: 4.530

Review 2.  Motivational activation: a unifying hypothesis of orexin/hypocretin function.

Authors:  Stephen V Mahler; David E Moorman; Rachel J Smith; Morgan H James; Gary Aston-Jones
Journal:  Nat Neurosci       Date:  2014-09-25       Impact factor: 24.884

3.  Decision making in narcolepsy with cataplexy.

Authors:  Sophie Bayard; Beatriz Abril; Huan Yu; Sabine Scholz; Bertrand Carlander; Yves Dauvilliers
Journal:  Sleep       Date:  2011-01-01       Impact factor: 5.849

4.  Evidence for metabolic hypothalamo-amygdala dysfunction in narcolepsy.

Authors:  Rositsa Poryazova; Betina Schnepf; Esther Werth; Ramin Khatami; Ulrike Dydak; Dieter Meier; Peter Boesiger; Claudio L Bassetti
Journal:  Sleep       Date:  2009-05       Impact factor: 5.849

5.  Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.

Authors:  Robert M Sears; Ann E Fink; Mattis B Wigestrand; Claudia R Farb; Luis de Lecea; Joseph E Ledoux
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-25       Impact factor: 11.205

6.  The Brain Correlates of Laugh and Cataplexy in Childhood Narcolepsy.

Authors:  Stefano Meletti; Anna Elisabetta Vaudano; Fabio Pizza; Andrea Ruggieri; Stefano Vandi; Alberto Teggi; Christian Franceschini; Francesca Benuzzi; Paolo Frigio Nichelli; Giuseppe Plazzi
Journal:  J Neurosci       Date:  2015-08-19       Impact factor: 6.167

7.  Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.

Authors:  Ashley M Blouin; Itzhak Fried; Charles L Wilson; Richard J Staba; Eric J Behnke; Hoa A Lam; Nigel T Maidment; Karl Æ Karlsson; Jennifer L Lapierre; Jerome M Siegel
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

8.  Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy.

Authors:  Sophie Bayard; Yves A Dauvilliers
Journal:  Front Behav Neurosci       Date:  2013-05-23       Impact factor: 3.558

9.  Orexin modulates behavioral fear expression through the locus coeruleus.

Authors:  Shingo Soya; Tohru M Takahashi; Thomas J McHugh; Takashi Maejima; Stefan Herlitze; Manabu Abe; Kenji Sakimura; Takeshi Sakurai
Journal:  Nat Commun       Date:  2017-11-20       Impact factor: 14.919

  9 in total

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