| Literature DB >> 17542770 |
Jaekyu Shin1, Julie A Johnson.
Abstract
Beta-blockers are an important cardiovascular drug class, recommended as first-line treatment of numerous diseases such as heart failure, hypertension, and angina, as well as treatment after myocardial infarction. However, responses to a beta-blocker are variable among patients. Results of numerous studies now suggest that genetic polymorphisms may contribute to variability in responses to beta-blockers. This review summarizes the pharmacogenetic data for beta-blockers in patients with various diseases and discusses the potential implications of beta-blocker pharmacogenetics in clinical practice.Entities:
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Year: 2007 PMID: 17542770 PMCID: PMC2735790 DOI: 10.1592/phco.27.6.874
Source DB: PubMed Journal: Pharmacotherapy ISSN: 0277-0008 Impact factor: 4.705