INTRODUCTION: The aim of this study was to explore the characteristics of off-label prescriptions of psychotropic drugs among patients hospitalised in psychiatry. METHODS: A one-day cross-sectional study was used to explore off-label prescribing in patients hospitalised in four wards of a state psychiatric hospital. Information regarding patients and treatment characteristics was collected from medical records. Off-label prescribing was defined according to the Summary of Product Characteristics. RESULTS: Seventy-five patients were included. Of the 261 prescriptions, more than one out of three (n=104, 39.8%) were off-label. Off-label prescribing was particularly high for anticonvulsants (97%), and to a lesser extent for mood stabilisers (33%) and anxiolytics (31%). The rate of off-label prescription was higher for 2nd compared to 1st generation antipsychotics. Most patients (84%) were prescribed at least one psychotropic drug outside of the licensed indication or recommended dosage. Patients with and without off-label prescription did not differ regarding history of prior admission, type of current admission (voluntary vs. compulsory) and diagnosis. CONCLUSION: In spite of its frequency in routine practice, off-label prescribing should not be trivialised. Prescribers should be better informed about the potential legal consequences of off-label prescribing.
INTRODUCTION: The aim of this study was to explore the characteristics of off-label prescriptions of psychotropic drugs among patients hospitalised in psychiatry. METHODS: A one-day cross-sectional study was used to explore off-label prescribing in patients hospitalised in four wards of a state psychiatric hospital. Information regarding patients and treatment characteristics was collected from medical records. Off-label prescribing was defined according to the Summary of Product Characteristics. RESULTS: Seventy-five patients were included. Of the 261 prescriptions, more than one out of three (n=104, 39.8%) were off-label. Off-label prescribing was particularly high for anticonvulsants (97%), and to a lesser extent for mood stabilisers (33%) and anxiolytics (31%). The rate of off-label prescription was higher for 2nd compared to 1st generation antipsychotics. Most patients (84%) were prescribed at least one psychotropic drug outside of the licensed indication or recommended dosage. Patients with and without off-label prescription did not differ regarding history of prior admission, type of current admission (voluntary vs. compulsory) and diagnosis. CONCLUSION: In spite of its frequency in routine practice, off-label prescribing should not be trivialised. Prescribers should be better informed about the potential legal consequences of off-label prescribing.
Authors: Gregory P Brown; Lynn A Stewart; Terry Rabinowitz; Harold Boudreau; Angela J Wright Journal: Can J Psychiatry Date: 2018-04-29 Impact factor: 4.356