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Literature DB >> 17541170

Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).

Kumiko Horiuchi¹, Sumiko Shiota, Tsutomu Hatano, Takashi Yoshida, Teruo Kuroda, Tomofusa Tsuchiya.

Abstract

An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid, a triterpenoid. We also tested antimicrobial activity of similar triterpenoids, ursolic acid, uvaol, betulinic acid and betulin. We found that ursolic acid also showed antimicrobial activity against VRE. The minimum inhibitory concentrations (MICs) of oleanolic acid and ursolic acid were 8 and 4 microg/ml, respectively. These two compounds also showed antimicrobial activity against Streptococcus pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA). These compounds showed bactericidal activity against VRE at least for 48 h when added at concentrations that were two-times higher than their MICs.

Entities: Chemical Species

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Year: 2007 PMID： 17541170 DOI： 10.1248/bpb.30.1147

Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233

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Cited

36 in total

1. Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli.

Authors: Anna M Grudniak; Anna Kurek; Jolanta Szarlak; Krystyna I Wolska
Journal: Curr Microbiol Date: 2011-01-09 Impact factor: 2.188

2. Biotransformation using Mucor rouxii for the production of oleanolic acid derivatives and their antimicrobial activity against oral pathogens.

Authors: Clarissa S Capel; Ana C D de Souza; Tatiane C de Carvalho; João P B de Sousa; Sérgio R Ambrósio; Carlos H G Martins; Wilson R Cunha; Rosario H Galán; Niege A J C Furtado
Journal: J Ind Microbiol Biotechnol Date: 2011-01-13 Impact factor: 3.346

10. Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

Authors: Lai Wah Chan; Emily L C Cheah; Constance L L Saw; Wanyu Weng; Paul W S Heng
Journal: Chin Med Date: 2008-11-28 Impact factor: 5.455

Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).

1. Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in Escherichia coli.

2. Biotransformation using Mucor rouxii for the production of oleanolic acid derivatives and their antimicrobial activity against oral pathogens.

Review 3. The Genus Alternanthera: Phytochemical and Ethnopharmacological Perspectives.

4. Antimicrobial Mechanism of Oleanolic and Ursolic Acids on Streptococcus mutans UA159.

5. Apoptotic and anti-angiogenic effects of Salvia triloba extract in prostate cancer cell lines.

6. Antimicrobial and antibiofilm effects of abietic acid on cariogenic Streptococcus mutans.

7. 3-Oxo-18α-olean-28,13β-olide.

8. Oleanolic acid and ursolic acid inhibit peptidoglycan biosynthesis in Streptococcus mutans UA159.

9. Structural and bioactive studies of terpenes and cyclopeptides from the Genus Rubia.

10. Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.