BACKGROUND: Previous studies indicate a survival advantage for women over men with chronic heart failure associated with reduced or preserved ejection fraction. Whether women with chronic heart failure are at less risk for hospitalization for worsening heart failure has not been well investigated. METHODS: Using data from the DIG trial, the relationship between sex and adverse outcomes, especially the risk of hospitalization for various causes, was evaluated in patients with reduced or preserved left ventricular ejection fraction. RESULTS:Survival was worse for men than women with either reduced (HR 1.48, 95% CI 1.33-1.65, P < .001) or preserved ejection fraction (HR 1.60, 95% CI 1.20-2.13, P = .001), with P =.406 for sex interaction. In contrast, the risk of hospitalization for heart failure was greater in men than women when ejection fraction was reduced (HR 1.19, 95% CI 1.07-1.33, P = .001) but not preserved (HR 0.90, 95% CI 0.67-1.22, P = .494), with P = .003 for sex interaction. The relative risk of hospitalization for worsening failure between reduced and preserved ejection fraction was greater in men than women (HR 5.97, 95% CI 1.40-25.56, P = .001 in men vs HR 2.65, 95% CI 0.68-10.31, P = .159 in women). CONCLUSION: A survival advantage for women was seen in heart failure with reduced or preserved ejection fraction. In contrast, women appeared to be at lower risk for hospitalization for heart failure only when left ventricular systolic dysfunction was present.
RCT Entities:
BACKGROUND: Previous studies indicate a survival advantage for women over men with chronic heart failure associated with reduced or preserved ejection fraction. Whether women with chronic heart failure are at less risk for hospitalization for worsening heart failure has not been well investigated. METHODS: Using data from the DIG trial, the relationship between sex and adverse outcomes, especially the risk of hospitalization for various causes, was evaluated in patients with reduced or preserved left ventricular ejection fraction. RESULTS: Survival was worse for men than women with either reduced (HR 1.48, 95% CI 1.33-1.65, P < .001) or preserved ejection fraction (HR 1.60, 95% CI 1.20-2.13, P = .001), with P =.406 for sex interaction. In contrast, the risk of hospitalization for heart failure was greater in men than women when ejection fraction was reduced (HR 1.19, 95% CI 1.07-1.33, P = .001) but not preserved (HR 0.90, 95% CI 0.67-1.22, P = .494), with P = .003 for sex interaction. The relative risk of hospitalization for worsening failure between reduced and preserved ejection fraction was greater in men than women (HR 5.97, 95% CI 1.40-25.56, P = .001 in men vs HR 2.65, 95% CI 0.68-10.31, P = .159 in women). CONCLUSION: A survival advantage for women was seen in heart failure with reduced or preserved ejection fraction. In contrast, women appeared to be at lower risk for hospitalization for heart failure only when left ventricular systolic dysfunction was present.
Authors: Saul Blecker; Kunihiro Matsushita; Ervin Fox; Stuart D Russell; Edgar R Miller; Herman Taylor; Frederick Brancati; Josef Coresh Journal: Am Heart J Date: 2010-09 Impact factor: 4.749
Authors: Mustafa I Ahmed; Mitja Lainscak; Marjan Mujib; Thomas E Love; Inmaculada Aban; Ileana L Piña; Wilbert S Aronow; Vera Bittner; Ali Ahmed Journal: Int J Cardiol Date: 2009-11-24 Impact factor: 4.164
Authors: Frank Edelmann; Raoul Stahrenberg; Götz Gelbrich; Kathleen Durstewitz; Christiane E Angermann; Hans-Dirk Düngen; Thomas Scheffold; Christian Zugck; Bernhard Maisch; Vera Regitz-Zagrosek; Gerd Hasenfuss; Burkert M Pieske; Rolf Wachter Journal: Clin Res Cardiol Date: 2011-03-17 Impact factor: 5.460