Literature DB >> 17539640

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Heather A Cooke1, Jian Zhang, Meghan A Griffin, Koichi Nonaka, Steven G Van Lanen, Ben Shen, Steven D Bruner.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17539640     DOI： 10.1021/ja071886a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


× No keyword cloud information.
  8 in total

1.  Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.

Authors:  Jianya Ling; Geoffrey P Horsman; Sheng-Xiong Huang; Yinggang Luo; Shuangjun Lin; Ben Shen
Journal:  J Am Chem Soc       Date:  2010-09-15       Impact factor: 15.419

2.  Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575.

Authors:  Lauren B Pickens; Woncheol Kim; Peng Wang; Hui Zhou; Kenji Watanabe; Shuichi Gomi; Yi Tang
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419

3.  Regiospecific O-methylation of naphthoic acids catalyzed by NcsB1, an O-methyltransferase involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Authors:  Yinggang Luo; Shuangjun Lin; Jian Zhang; Heather A Cooke; Steven D Bruner; Ben Shen
Journal:  J Biol Chem       Date:  2008-04-03       Impact factor: 5.157

4.  Molecular basis of substrate promiscuity for the SAM-dependent O-methyltransferase NcsB1, involved in the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

Authors:  Heather A Cooke; Elizabeth L Guenther; Yinggang Luo; Ben Shen; Steven D Bruner
Journal:  Biochemistry       Date:  2009-10-13       Impact factor: 3.162

5.  Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.

Authors:  Steven G Van Lanen; Tae-Jin Oh; Wen Liu; Evelyn Wendt-Pienkowski; Ben Shen
Journal:  J Am Chem Soc       Date:  2007-10-06       Impact factor: 15.419

6.  Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Authors:  Jeremy R Lohman; Sheng-Xiong Huang; Geoffrey P Horsman; Paul E Dilfer; Tingting Huang; Yihua Chen; Evelyn Wendt-Pienkowski; Ben Shen
Journal:  Mol Biosyst       Date:  2013-01-29

7.  Characterization of the calicheamicin orsellinate C2-O-methyltransferase CalO6.

Authors:  Shanteri Singh; Nitin S Nandurkar; Jon S Thorson
Journal:  Chembiochem       Date:  2014-07-07       Impact factor: 3.164

8.  Elucidation of salicylate attachment in celesticetin biosynthesis opens the door to create a library of more efficient hybrid lincosamide antibiotics.

Authors:  S Kadlcik; Z Kamenik; D Vasek; M Nedved; J Janata
Journal:  Chem Sci       Date:  2017-03-23       Impact factor: 9.825
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.