Literature DB >> 17539158

Assessment of testicular toxicity in laboratory animals.

R Heywood, R W James.   

Abstract

The currently available methods of assessing testicular toxicity and fertility are discussed. Compounds inducing testicular atrophy mainly affect the seminiferous epithelium, with progressive loss of spermatozoa, spermatids, spermatocytes, and spermatogonia. Quantitative histometric analysis of spermatogenesis, together with hormone assays, could be used to advantage in defining the underlying mechanisms of toxicity.

Entities:  

Year:  1978        PMID： 17539158      PMCID： PMC1637228          DOI： 10.1289/ehp.782473

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  5 in total

1.  Atrophy of rat testis as index of chemical toxicity.

Authors:  W E RIBELIN
Journal:  Arch Pathol       Date:  1963-03

2.  Allometric analysis of organ weights: II. Beagle dogs.

Authors:  L Lützen; G Trieb; G Pappritz
Journal:  Toxicol Appl Pharmacol       Date:  1976-03       Impact factor: 4.219

3.  An annual rhythm in the plasma testosterone of adult male rhesus monkeys maintained in the laboratory.

Authors:  T M Plant; D Zumpe; M Sauls; R P Michael
Journal:  J Endocrinol       Date:  1974-08       Impact factor: 4.286

4.  Short-term toxicity of cyclohexylamine hydrochloride in the rat.

Authors:  I F Gaunt; M Sharratt; P Grasso; A B Lansdown; S D Gangolli
Journal:  Food Cosmet Toxicol       Date:  1974-10

5.  The neuroleptics. 4. Toxicity and side effects in man and in the laboratory animal.

Authors:  R Degkwitz; C Heushgem; L E Hollister; J Jacob; L Julou; P A Lambert; R Marsboom; W Meier-Ruge; W K Schaper; H C Tuchmann-Duplessis
Journal:  Mod Probl Pharmacopsychiatry       Date:  1970
  5 in total

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