Literature DB >> 17537934

Rapid detection directly from patient serum samples of human cytomegalovirus UL97 mutations conferring ganciclovir resistance.

Jared Castor1, Linda Cook, Lawrence Corey, Keith R Jerome.   

Abstract

Ganciclovir-resistant cytomegalovirus can cause disease and death in transplant recipients. We describe here a rapid PCR- and sequencing-based assay for ganciclovir resistance that can be performed in 1 to 2 working days directly from patient specimens, without the need for amplification of the virus by cell culture. An evaluation of 120 sequential samples submitted for clinical testing revealed a variety of silent and amino acid mutations.

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Year:  2007        PMID： 17537934      PMCID： PMC1951258          DOI： 10.1128/JCM.00526-07

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

1.  Comparison of cytomegalovirus (CMV) UL97 gene sequences in the blood and vitreous of patients with acquired immunodeficiency syndrome and CMV retinitis.

Authors:  Huiling Hu; Douglas A Jabs; Michael S Forman; Barbara K Martin; J P Dunn; David V Weinberg; Janet L Davis
Journal:  J Infect Dis       Date:  2002-03-19       Impact factor: 5.226

2.  Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients.

Authors:  Alain Coaquette; Alain Bourgeois; Carine Dirand; Audrey Varin; Wan Chen; Georges Herbein
Journal:  Clin Infect Dis       Date:  2004-06-23       Impact factor: 9.079

3.  Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR.

Authors:  Michael Boeckh; MeeiLi Huang; James Ferrenberg; Terry Stevens-Ayers; Laurence Stensland; W Garrett Nichols; Lawrence Corey
Journal:  J Clin Microbiol       Date:  2004-03       Impact factor: 5.948

Review 4.  Human cytomegalovirus resistance to antiviral drugs.

Authors:  C Gilbert; G Boivin
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

5.  Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing.

Authors:  N S Lurain; A Weinberg; C S Crumpacker; S Chou
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

Review 6.  Molecular detection of human cytomegalovirus and determination of genotypic ganciclovir resistance in clinical specimens.

Authors:  S A Spector; K Hsia; D Wolf; M Shinkai; I Smith
Journal:  Clin Infect Dis       Date:  1995-10       Impact factor: 9.079

Review 7.  Resistance of herpesviruses to antiviral drugs: clinical impacts and molecular mechanisms.

Authors:  Christian Gilbert; Julie Bestman-Smith; Guy Boivin
Journal:  Drug Resist Updat       Date:  2002-04       Impact factor: 18.500

Review 8.  Antiviral resistance in cytomegalovirus: an emerging problem in organ transplant recipients.

Authors:  Ajit P Limaye
Journal:  Semin Respir Infect       Date:  2002-12

9.  Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.

Authors:  D G Wolf; I L Smith; D J Lee; W R Freeman; M Flores-Aguilar; S A Spector
Journal:  J Clin Invest       Date:  1995-01       Impact factor: 14.808

10.  Detection of ganciclovir resistance in patients with AIDS and cytomegalovirus retinitis: correlation of genotypic methods with viral phenotype and clinical outcome.

Authors:  Douglas A Jabs; Barbara K Martin; Michelle O Ricks; Michael S Forman
Journal:  J Infect Dis       Date:  2006-05-10       Impact factor: 5.226
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  12 in total

1.  Recombinant phenotyping of cytomegalovirus UL97 kinase sequence variants for ganciclovir resistance.

Authors:  Sunwen Chou
Journal:  Antimicrob Agents Chemother       Date:  2010-04-12       Impact factor: 5.191

2.  Improved detection of mutated human cytomegalovirus UL97 by pyrosequencing.

Authors:  Birgit Schindele; Luise Apelt; Jörg Hofmann; Andreas Nitsche; Detlef Michel; Sebastian Voigt; Thomas Mertens; Bernhard Ehlers
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

3.  Valganciclovir for the prevention of complications of late cytomegalovirus infection after allogeneic hematopoietic cell transplantation: a randomized trial.

Authors:  Michael Boeckh; W Garrett Nichols; Roy F Chemaly; Genovefa A Papanicolaou; John R Wingard; Hu Xie; Karen L Syrjala; Mary E D Flowers; Terry Stevens-Ayers; Keith R Jerome; Wendy Leisenring
Journal:  Ann Intern Med       Date:  2015-01-06       Impact factor: 25.391

4.  Primary response against cytomegalovirus during antiviral prophylaxis with valganciclovir, in solid organ transplant recipients.

Authors:  Corinna La Rosa; Ajit P Limaye; Aparna Krishnan; Gideon Blumstein; Jeff Longmate; Don J Diamond
Journal:  Transpl Int       Date:  2011-06-14       Impact factor: 3.782

5.  Molecular analysis of varicella vaccines and varicella-zoster virus from vaccine-related skin lesions.

Authors:  Sonja Thiele; Aljona Borschewski; Judit Küchler; Marc Bieberbach; Sebastian Voigt; Bernhard Ehlers
Journal:  Clin Vaccine Immunol       Date:  2011-05-11

6.  Risk Factors and Outcomes of Ganciclovir-Resistant Cytomegalovirus Infection in Solid Organ Transplant Recipients.

Authors:  Cynthia E Fisher; Janine L Knudsen; Erika D Lease; Keith R Jerome; Robert M Rakita; Michael Boeckh; Ajit P Limaye
Journal:  Clin Infect Dis       Date:  2017-07-01       Impact factor: 9.079

7.  Successful ganciclovir treatment of primary cytomegalovirus infection containing the UL97 mutation N510S in an intestinal graft recipient.

Authors:  R Bachmann; K Hamprecht; J Lange; R Ladurner; S Nadalin; G Jahn; A Königsrainer; A Heininger
Journal:  Infection       Date:  2013-04-02       Impact factor: 3.553

8.  Pyrosequencing allows the detection of emergent ganciclovir resistance mutations after HCMV infection.

Authors:  Susanne E Kampmann; Birgit Schindele; Luise Apelt; Christoph Bührer; Lars Garten; Katharina Weizsaecker; Detlev H Krüger; Bernhard Ehlers; Jörg Hofmann
Journal:  Med Microbiol Immunol       Date:  2010-12-17       Impact factor: 3.402

9.  Rapid detection of human cytomegalovirus UL97 and UL54 mutations directly from patient samples.

Authors:  Ruth Hall Sedlak; Jared Castor; Susan M Butler-Wu; Elaine Chan; Linda Cook; Ajit P Limaye; Keith R Jerome
Journal:  J Clin Microbiol       Date:  2013-05-15       Impact factor: 5.948

10.  Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R- transplant recipients.

Authors:  Nancy Perrottet; Oriol Manuel; Frédéric Lamoth; Jean-Pierre Venetz; Roland Sahli; Laurent A Decosterd; Thierry Buclin; Manuel Pascual; Pascal Meylan
Journal:  BMC Infect Dis       Date:  2010-01-06       Impact factor: 3.090
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