OBJECTIVES: The ratio of the urinary mass concentrations of cystatin C and creatinine (UcysC/Ucrea)>/=11.3 mg/mmol has recently been proposed as an accurate marker for the detection of GFR</=60 mL/min/1.73 m(2). DESIGN AND METHODS: We prospectively evaluated the diagnostic performance of UcysC/Ucrea>/=11.3 mg/mmol and factors associated with increased UcysC/Ucrea in 72 children and adults with a wide variety of renal disorders. UcysC/Ucrea was calculated, and GFR wad estimated from serum creatinine and cystatin C by equations. RESULTS: UcysC/Ucrea>/=11.3 mg/mmol had a low diagnostic value to detect GFR values</=60 mL/min/1.73 m(2) estimated by creatinine or cystatin-C-based equations with sensitivities of 72% and 63%, and specificities of 42% and 34%. ROC curves for UcysC/Ucrea to detect GFR</=60 mL/min/1.73 m(2) confirmed this with AUCs of 0.59 for creatinine and 0.57 for cystatin-C-based equations. Multivariate analysis identified tubular proteinuria, tubulointerstitial disease and heavy proteinuria, but not GFR</=60 mL/min/1.73 m(2), as factors independently associated with increased UcysC/Ucrea. CONCLUSIONS: UcysC/Ucrea>/=11.3 mg/mmol is not an accurate marker to detect GFR</=60 mL/min/1.73 m(2), but reflects tubular dysfunction and proteinuria due to heavy proteinuria and tubulointerstitial disease.
OBJECTIVES: The ratio of the urinary mass concentrations of cystatin C and creatinine (UcysC/Ucrea)>/=11.3 mg/mmol has recently been proposed as an accurate marker for the detection of GFR</=60 mL/min/1.73 m(2). DESIGN AND METHODS: We prospectively evaluated the diagnostic performance of UcysC/Ucrea>/=11.3 mg/mmol and factors associated with increased UcysC/Ucrea in 72 children and adults with a wide variety of renal disorders. UcysC/Ucrea was calculated, and GFR wad estimated from serum creatinine and cystatin C by equations. RESULTS: UcysC/Ucrea>/=11.3 mg/mmol had a low diagnostic value to detect GFR values</=60 mL/min/1.73 m(2) estimated by creatinine or cystatin-C-based equations with sensitivities of 72% and 63%, and specificities of 42% and 34%. ROC curves for UcysC/Ucrea to detect GFR</=60 mL/min/1.73 m(2) confirmed this with AUCs of 0.59 for creatinine and 0.57 for cystatin-C-based equations. Multivariate analysis identified tubular proteinuria, tubulointerstitial disease and heavy proteinuria, but not GFR</=60 mL/min/1.73 m(2), as factors independently associated with increased UcysC/Ucrea. CONCLUSIONS: UcysC/Ucrea>/=11.3 mg/mmol is not an accurate marker to detect GFR</=60 mL/min/1.73 m(2), but reflects tubular dysfunction and proteinuria due to heavy proteinuria and tubulointerstitial disease.
Authors: Frank Dieterle; Elias Perentes; André Cordier; Daniel R Roth; Pablo Verdes; Olivier Grenet; Serafino Pantano; Pierre Moulin; Daniel Wahl; Andreas Mahl; Peter End; Frank Staedtler; François Legay; Kevin Carl; David Laurie; Salah-Dine Chibout; Jacky Vonderscher; Gérard Maurer Journal: Nat Biotechnol Date: 2010-05 Impact factor: 54.908
Authors: Jabbar Saliba; Nader R Kasim; Robyn A Tamboli; James M Isbell; Pam Marks; Irene D Feurer; Alp Ikizler; Naji N Abumrad Journal: Surgery Date: 2009-12-11 Impact factor: 3.982