BACKGROUND: The T allele of the hepatic lipase (HL) C-480T polymorphism was previously found to be associated with lower post-heparin plasma HL activity, atherosclerosis and risk of coronary artery disease. We studied the association of HL C-480T polymorphism with the extent of atherosclerosis at vessel-wall level in an autopsy series of middle-aged men. MATERIALS AND METHODS: An autopsy cohort of 700 Caucasian Finnish men aged 33-70 years (mean 53 years), which comprised two autopsy series, collected 10 years apart during 1981-82 and 1991-92, were analysed. Areas of coronary wall covered with fatty streaks and fibrotic and complicated lesions were measured using computer-assisted planimetry and related to HL C-480T genotypes (CC, CT, and TT). RESULTS: There was a significant age-by-genotype interaction on the mean percentage area of fatty streaks (P = 0.01). The HL C-480T polymorphism was a significant explanatory factor for fatty streak area in men under 53 years of age with or without age, body mass index, hypertension, diabetes, smoking, alcohol consumption, apolipoprotein E genotype, and series number as covariates. Men carrying the TT genotype had two times larger areas of fatty streaks compared to the CC carriers (8.8% vs. 4.3%, P = 0.009). However, this association disappeared in men over 53 years. The areas of more advanced atherosclerotic lesions did not vary significantly among the genotype groups. CONCLUSIONS: Our results suggest that the HL C-480T polymorphism affects the formation of early coronary atherosclerotic lesions in men in their early middle age.
BACKGROUND: The T allele of the hepatic lipase (HL) C-480T polymorphism was previously found to be associated with lower post-heparin plasma HL activity, atherosclerosis and risk of coronary artery disease. We studied the association of HL C-480T polymorphism with the extent of atherosclerosis at vessel-wall level in an autopsy series of middle-aged men. MATERIALS AND METHODS: An autopsy cohort of 700 Caucasian Finnish men aged 33-70 years (mean 53 years), which comprised two autopsy series, collected 10 years apart during 1981-82 and 1991-92, were analysed. Areas of coronary wall covered with fatty streaks and fibrotic and complicated lesions were measured using computer-assisted planimetry and related to HL C-480T genotypes (CC, CT, and TT). RESULTS: There was a significant age-by-genotype interaction on the mean percentage area of fatty streaks (P = 0.01). The HL C-480T polymorphism was a significant explanatory factor for fatty streak area in men under 53 years of age with or without age, body mass index, hypertension, diabetes, smoking, alcohol consumption, apolipoprotein E genotype, and series number as covariates. Men carrying the TT genotype had two times larger areas of fatty streaks compared to the CC carriers (8.8% vs. 4.3%, P = 0.009). However, this association disappeared in men over 53 years. The areas of more advanced atherosclerotic lesions did not vary significantly among the genotype groups. CONCLUSIONS: Our results suggest that the HL C-480T polymorphism affects the formation of early coronary atherosclerotic lesions in men in their early middle age.
Authors: Glenn I Fishman; Sumeet S Chugh; John P Dimarco; Christine M Albert; Mark E Anderson; Robert O Bonow; Alfred E Buxton; Peng-Sheng Chen; Mark Estes; Xavier Jouven; Raymond Kwong; David A Lathrop; Alice M Mascette; Jeanne M Nerbonne; Brian O'Rourke; Richard L Page; Dan M Roden; David S Rosenbaum; Nona Sotoodehnia; Natalia A Trayanova; Zhi-Jie Zheng Journal: Circulation Date: 2010-11-30 Impact factor: 29.690
Authors: Marco V Perez; Matthew Wheeler; Michael Ho; Aleksandra Pavlovic; Paul Wang; Euan A Ashley Journal: J Cardiovasc Transl Res Date: 2008-05-15 Impact factor: 4.132
Authors: Yue-Mei Fan; Pekka J Karhunen; Mari Levula; Erkki Ilveskoski; Jussi Mikkelsson; Olli A Kajander; Otso Järvinen; Niku Oksala; Janita Thusberg; Mauno Vihinen; Juha-Pekka Salenius; Leena Kytömäki; Juhani T Soini; Reijo Laaksonen; Terho Lehtimäki Journal: Thromb J Date: 2008-12-30