Literature DB >> 17536163

Molecular chaperones: the modular evolution of cellular networks.

Tamás Korcsmáros1, István A Kovács, Máté S Szalay, Péter Csermely.   

Abstract

Molecular chaperones play a prominent role in signaling and transcriptional regulatory networks of the cell. Recent advances uncovered that chaperones act as genetic buffers stabilizing the phenotype of various cells and organisms and may serve as potential regulators of evolvability. Chaperones have weak links, connect hubs, are in the overlaps of network modules and may uncouple these modules during stress,which gives an additional protection for the cell at the network-level. Moreover,after stress chaperones are essential to re-build inter-modular contacts by their low affinity sampling of the potential interaction partners in different modules. This opens the way to the chaperone-regulated modular evolution of cellular networks,and helps us to design novel therapeutic and anti-aging strategies.

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Year:  2007        PMID： 17536163     DOI： 10.1007/s12038-007-0043-y

Source DB:  PubMed          Journal:  J Biosci        ISSN： 0250-5991            Impact factor:   1.826


  27 in total

1.  Endosymbiotic bacteria: groEL buffers against deleterious mutations.

Authors:  Mario A Fares; Mario X Ruiz-González; Andrés Moya; Santiago F Elena; Eladio Barrio
Journal:  Nature       Date:  2002-05-23       Impact factor: 49.962

2.  Chaperone function and chaperone overload in the aged. A preliminary analysis.

Authors:  Gábor Nardai; Péter Csermely; Csaba Söti
Journal:  Exp Gerontol       Date:  2002 Oct-Nov       Impact factor: 4.032

3.  The metabolic world of Escherichia coli is not small.

Authors:  Masanori Arita
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-02       Impact factor: 11.205

Review 4.  Network biology: understanding the cell's functional organization.

Authors:  Albert-László Barabási; Zoltán N Oltvai
Journal:  Nat Rev Genet       Date:  2004-02       Impact factor: 53.242

Review 5.  Molecular chaperones as regulatory elements of cellular networks.

Authors:  Csaba Soti; Csaba Pál; Balázs Papp; Péter Csermely
Journal:  Curr Opin Cell Biol       Date:  2005-04       Impact factor: 8.382

Review 6.  The efficiency of multi-target drugs: the network approach might help drug design.

Authors:  Péter Csermely; Vilmos Agoston; Sándor Pongor
Journal:  Trends Pharmacol Sci       Date:  2005-04       Impact factor: 14.819

7.  Towards a proteome-scale map of the human protein-protein interaction network.

Authors:  Jean-François Rual; Kavitha Venkatesan; Tong Hao; Tomoko Hirozane-Kishikawa; Amélie Dricot; Ning Li; Gabriel F Berriz; Francis D Gibbons; Matija Dreze; Nono Ayivi-Guedehoussou; Niels Klitgord; Christophe Simon; Mike Boxem; Stuart Milstein; Jennifer Rosenberg; Debra S Goldberg; Lan V Zhang; Sharyl L Wong; Giovanni Franklin; Siming Li; Joanna S Albala; Janghoo Lim; Carlene Fraughton; Estelle Llamosas; Sebiha Cevik; Camille Bex; Philippe Lamesch; Robert S Sikorski; Jean Vandenhaute; Huda Y Zoghbi; Alex Smolyar; Stephanie Bosak; Reynaldo Sequerra; Lynn Doucette-Stamm; Michael E Cusick; David E Hill; Frederick P Roth; Marc Vidal
Journal:  Nature       Date:  2005-09-28       Impact factor: 49.962

8.  Some protein interaction data do not exhibit power law statistics.

Authors:  Reiko Tanaka; Tau-Mu Yi; John Doyle
Journal:  FEBS Lett       Date:  2005-09-26       Impact factor: 4.124

9.  Chance and necessity in the evolution of minimal metabolic networks.

Authors:  Csaba Pál; Balázs Papp; Martin J Lercher; Péter Csermely; Stephen G Oliver; Laurence D Hurst
Journal:  Nature       Date:  2006-03-30       Impact factor: 49.962

10.  Yeast Protein Interactome topology provides framework for coordinated-functionality.

Authors:  André X C N Valente; Michael E Cusick
Journal:  Nucleic Acids Res       Date:  2006-05-22       Impact factor: 16.971
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  16 in total

1.  Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis.

Authors:  Yasmine Draceni; Sebastian Pechmann
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-16       Impact factor: 11.205

Review 2.  Chaperome Networks - Redundancy and Implications for Cancer Treatment.

Authors:  Pengrong Yan; Tai Wang; Monica L Guzman; Radu I Peter; Gabriela Chiosis
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

3.  Triggers of the HSP70 stress response: environmental responses and laboratory manipulation in an Antarctic marine invertebrate (Nacella concinna).

Authors:  Melody S Clark; Lloyd S Peck
Journal:  Cell Stress Chaperones       Date:  2009-04-30       Impact factor: 3.667

Review 4.  Heat shock genes - integrating cell survival and death.

Authors:  Richa Arya; Moushami Mallik; Subhash C Lakhotia
Journal:  J Biosci       Date:  2007-04       Impact factor: 1.826

5.  Functional organization of the yeast proteome by a yeast interactome map.

Authors:  André X C N Valente; Seth B Roberts; Gregory A Buck; Yuan Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-21       Impact factor: 11.205

6.  Antarctic krill 454 pyrosequencing reveals chaperone and stress transcriptome.

Authors:  Melody S Clark; Michael A S Thorne; Jean-Yves Toullec; Yan Meng; Le Luo Guan; Lloyd S Peck; Stephen Moore
Journal:  PLoS One       Date:  2011-01-06       Impact factor: 3.240

7.  Heat shock partially dissociates the overlapping modules of the yeast protein-protein interaction network: a systems level model of adaptation.

Authors:  Ágoston Mihalik; Peter Csermely
Journal:  PLoS Comput Biol       Date:  2011-10-13       Impact factor: 4.475

8.  POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data.

Authors:  Joana P Gonçalves; Mário Grãos; André X C N Valente
Journal:  J R Soc Interface       Date:  2008-11-28       Impact factor: 4.118

9.  Surviving the cold: molecular analyses of insect cryoprotective dehydration in the Arctic springtail Megaphorura arctica (Tullberg).

Authors:  Melody S Clark; Michael As Thorne; Jelena Purać; Gavin Burns; Guy Hillyard; Zeljko D Popović; Gordana Grubor-Lajsić; M Roger Worland
Journal:  BMC Genomics       Date:  2009-07-21       Impact factor: 3.969

Review 10.  Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior.

Authors:  Ildefonso M De la Fuente; Luis Martínez; Jose Carrasco-Pujante; Maria Fedetz; José I López; Iker Malaina
Journal:  Front Genet       Date:  2021-05-21       Impact factor: 4.599
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