Literature DB >> 17535300

Characterization of epitopes recognized by anti-Streptococcus mutans P1 monoclonal antibodies.

William P McArthur1, Nikki R Rhodin, Trevor B Seifert, Monika W Oli, Rebekah A Robinette, Donald R Demuth, L Jeannine Brady.   

Abstract

Sequences contributing to epitopes recognized by a panel of monoclonal antibodies (mAbs) against the Streptococcus mutans surface protein P1 were delineated by Western blot and enzyme-linked immunosorbent assay using a battery of deletion constructs and recombinant polypeptides. mAbs that recognize complex discontinuous epitopes reconstituted by combining the alanine-rich and proline-rich repeat domains and varying degrees of flanking sequence were identified as well as mAbs that bound epitopes contained within contiguous segments of P1. Cross-reactivity with SspA and SspB from Streptococcus gordonii is also reported. This information enables insight into the structure and function of a streptococcal adhesin and its correlates of protection and furthers our understanding of the immunomodulatory and bacterial-adherence inhibition activities of anti-P1 mAbs.

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Year:  2007        PMID： 17535300     DOI： 10.1111/j.1574-695X.2007.00260.x

Source DB:  PubMed          Journal:  FEMS Immunol Med Microbiol        ISSN： 0928-8244


  18 in total

1.  Identification of a supramolecular functional architecture of Streptococcus mutans adhesin P1 on the bacterial cell surface.

Authors:  Kyle P Heim; Ruby May A Sullan; Paula J Crowley; Sofiane El-Kirat-Chatel; Audrey Beaussart; Wenxing Tang; Richard Besingi; Yves F Dufrene; L Jeannine Brady
Journal:  J Biol Chem       Date:  2015-02-09       Impact factor: 5.157

2.  Requirements for surface expression and function of adhesin P1 from Streptococcus mutans.

Authors:  Paula J Crowley; Trevor B Seifert; Ryutaro Isoda; Marloes van Tilburg; Monika W Oli; Rebekah A Robinette; William P McArthur; Arnold S Bleiweis; L Jeannine Brady
Journal:  Infect Immun       Date:  2008-03-24       Impact factor: 3.441

3.  An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1.

Authors:  Kyle P Heim; Paula J Crowley; Joanna R Long; Shweta Kailasan; Robert McKenna; L Jeannine Brady
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-20       Impact factor: 11.205

4.  A therapeutic anti-Streptococcus mutans monoclonal antibody used in human passive protection trials influences the adaptive immune response.

Authors:  Rebekah A Robinette; Monika W Oli; William P McArthur; L Jeannine Brady
Journal:  Vaccine       Date:  2011-06-23       Impact factor: 3.641

5.  YidC1 and YidC2 are functionally distinct proteins involved in protein secretion, biofilm formation and cariogenicity of Streptococcus mutans.

Authors:  Sara R Palmer; Paula J Crowley; Monika W Oli; M Adam Ruelf; Suzanne M Michalek; L Jeannine Brady
Journal:  Microbiology       Date:  2012-04-13       Impact factor: 2.777

6.  Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of alpha- and PPII-helices.

Authors:  Matthew R Larson; Kanagalaghatta R Rajashankar; Manisha H Patel; Rebekah A Robinette; Paula J Crowley; Suzanne Michalek; L Jeannine Brady; Champion Deivanayagam
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-15       Impact factor: 11.205

7.  Alterations in immunodominance of Streptococcus mutans AgI/II: lessons learned from immunomodulatory antibodies.

Authors:  Rebekah A Robinette; Kyle P Heim; Monika W Oli; Paula J Crowley; William P McArthur; L Jeannine Brady
Journal:  Vaccine       Date:  2013-11-16       Impact factor: 3.641

8.  Evaluation of the effects of Streptococcus mutans chaperones and protein secretion machinery components on cell surface protein biogenesis, competence, and mutacin production.

Authors:  P J Crowley; L J Brady
Journal:  Mol Oral Microbiol       Date:  2015-10-07       Impact factor: 3.563

9.  An intramolecular interaction involving the N terminus of a streptococcal adhesin affects its conformation and adhesive function.

Authors:  Kyle P Heim; Paula J Crowley; L Jeannine Brady
Journal:  J Biol Chem       Date:  2013-03-28       Impact factor: 5.157

10.  Beneficial immunomodulation by Streptococcus mutans anti-P1 monoclonal antibodies is Fc independent and correlates with increased exposure of a relevant target epitope.

Authors:  Rebekah A Robinette; Monika W Oli; William P McArthur; L Jeannine Brady
Journal:  J Immunol       Date:  2009-09-14       Impact factor: 5.422
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